NEUROPROTECTION WITH GLUTAMATE AND ARNICA MONTANA

描述：非导弹引起的神经退行性疾病和脑损伤 在美国，头部创伤占了近50万的入院人数。 每年一次。虽然病因可能不同，但相同的解剖和生理学 底物参与了这些情况，包括缺血和缺氧。 损伤与兴奋性氨基酸，特别是谷氨酸的释放 病变或受损的细胞。我们一直在使用体外和体内模型 实验性脑缺血与谷氨酸毒性的细胞模型研究 这些神经损伤的机制，并针对性的早期干预治疗 神经退行性变的策略。 一种尚未被探索的有希望的策略是使用低剂量的 增强细胞耐受性和恢复能力的化学物质。高剂量的有毒化学物质 会抑制和杀死生物系统，而低剂量经常刺激 那些系统。低剂量染毒对细胞功能的刺激作用 化学品通常可以减轻高剂量产生的不利影响。这 现象是顺势疗法中观察到的效应的理论基础。 虽然矛盾的剂量效应在多种类型的细胞中都被证明 和门，它们还没有在神经退行性变中进行检查。在预赛中 研究表明，保护作用发生在神经细胞中。 暴露在低剂量和超低剂量谷氨酸以及超低剂量谷氨酸中 谷氨酸和顺势疗法的山金车可以显著减少脑损伤 来自体内的缺血。 这个项目的目标是使用神经元培养系统和缺血 脑损伤模型以确定最佳保护剂量和途径 谷氨酸和顺势疗法蒙大拿山金车暴露。一旦这些剂量达到 确定我们将检查这些制剂的体内效应以靶向 未来的机制和临床研究。我们将开发出，为了 首次建立了保护性兴奋科学研究的系统模型 神经退行性变和脑损伤的顺势疗法。

DESCRIPTION: Diseases of neurodegeneration and brain damage from non-missile head trauma account for nearly 500,000 hospital admissions in the U.S. annually. Although the etiology may differ, the same anatomic and physiologic substrates are involved in these conditions, including ischemia and hypoxic injury and the release of excitatory amino acids, especially glutamate from diseased or damaged cells. We have been using in vitro and in vivo models of experimental ischemia and cellular models of glutamate toxicity to examine these mechanisms of neuronal injury, and to target early intervention treatment strategies for neurodegeneration. One promising strategy that has not been explored is the use of low doses of chemicals to enhance cell tolerance and recovery. High doses of toxic chemicals will inhibit and kill biological systems, while low doses frequently stimulate those systems. Stimulation of cell function by exposure to low doses of chemicals can often mitigate the adverse effects produced by high doses. This phenomenon is the theoretical basis for the observed effects in homeopathy. While paradoxical dose effects been demonstrated across multiple cells types and phyla they have not yet been examined in neurodegeneration. In preliminary research we have demonstrated that protective effects occur in neuronal cells exposed to low and ultra-low doses of glutamate and that ultra-low dose glutamate and homeopathic Arnica montana can significantly reduce brain damage from ischemia in vivo. The objective of this project is to use neuronal culture systems and ischemia models of brain injury to identify the optimal protective doses and routes of glutamate and homeopathic Arnica montana exposure. Once these dosages are identified we will examine the in vivo effects of these preparations to target mechanism and clinical studies in the future. We will have developed, for the first time, a systematic model for the scientific study of protective hormesis and homeopathy in neurodegeneration and brain injury.