2000 FASEB CONFERENCE ON PROTEIN PHOSPHATASES

2000 年 FASEB 蛋白磷酸酶会议

• 批准号: 6190269
• 负责人: ANNA A DEPAOLI-ROACH
• 金额: $ 1.6万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6190269
• 关键词: meeting /conference /symposium; phosphoprotein phosphatase; travel

This application seeks partial support for a FASEB Summer Conference on Protein Phosphatases to be held from July 23 to July 28, 2000 at Copper Mountain, Colorado. This will mark the tenth anniversary of this meeting. At the dawn of a new millennium, the success of the previous conferences and the widely recognized role of these enzymes in regulation of many cellular functions amply justify the existence of such a conference. Research on protein phosphatases is at an exciting and rapidly moving stage, revealing the fundamental importance of these enzymes in pathways that govern most aspects of cell life and death. It is now clear that phosphatases are equal partners with protein kinases and research on protein phosphatases is essential for our understanding of the control of cellular functions. Within the past few years, a large number of phosphatases and phosphatase regulatory/targeting subunits have been identified. A major focus of current research is to understand their physiological role and the multiplicity of ways they are involved in signaling. Protein phosphatases offer potential targets for development of new and specific pharmacological agents. Phosphatases have already been identified as the targets for immunosuppressant drugs, tumor promoters, DNA tumor viruses and a wide variety of natural toxins. PTEN, a member of the family of dual specificity phosphatases, has recently been identified as the product of a tumor suppressor gene. The involvement of PP2B/calcineurin in skeletal and cardiac muscle hypertrophy has become apparent and the PTP1B has been implicated in insulin action and obesity. The purpose of this conference is to bring together investigators studying various aspects of protein phosphatases and to disseminate the most recent information in the field. There is a constant infusion of new researchers from various disciplines into this area and the 2000 conference will be important for a focused presentation and discussion of the most recent advances in the genetics, biochemistry and function of protein phosphatases. The Conference will consist of eight sessions, each with at least six speakers, selected from investigators who have made important recent contributions and from submitted abstracts. This will help to ensure inclusion of young investigators, women and minorities as primary participants. In addition, two poster sessions will be organized. Overall, rapid progress is being made in the identification of the diverse functions of protein phosphatases in normal and pathological conditions, such as diabetes, cancer, neurodegenerative conditions, developmental and immunological defects and cardiovascular diseases.

本申请寻求对将于2000年7月23日至7月28日在科罗拉多铜山举行的FASEB蛋白磷酸酶夏季会议的部分支持。 这将标志着这次会议十周年。 在新千年的黎明，以前的会议的成功和这些酶在调节许多细胞功能中的广泛认可的作用充分证明了这样一个会议的存在。对蛋白磷酸酶的研究正处于一个令人兴奋和快速发展的阶段，揭示了这些酶在控制细胞生命和死亡的大多数方面的途径中的根本重要性。 现在很清楚，磷酸酶与蛋白激酶是平等的伙伴，对蛋白磷酸酶的研究对于我们理解细胞功能的控制至关重要。在过去的几年中，已经鉴定了大量的磷酸酶和磷酸酶调节/靶向亚基。目前研究的一个主要焦点是了解它们的生理作用以及它们参与信号传导的多种方式。 蛋白磷酸酶为开发新的和特异性的药理学试剂提供了潜在的靶点。磷酸酶已被确定为免疫抑制剂、肿瘤促进剂、DNA肿瘤病毒和各种天然毒素的靶点。 PTEN是双特异性磷酸酶家族的成员，最近被鉴定为肿瘤抑制基因的产物。 PP 2B/钙调神经磷酸酶参与骨骼肌和心肌肥大已变得明显，PTP 1B与胰岛素作用和肥胖有关。这次会议的目的是汇集研究人员研究蛋白磷酸酶的各个方面，并传播该领域的最新信息。 有一个不断注入新的研究人员从各个学科到这一领域和2000年的会议将是重要的集中介绍和讨论的最新进展的遗传学，生物化学和功能的蛋白磷酸酶。 会议将包括八次会议，每次会议至少有六名发言者，从最近作出重要贡献的研究人员和提交的摘要中选出。 这将有助于确保将年轻调查员、妇女和少数民族作为主要参与者。 此外，还将举办两次海报展示会。总体而言，在鉴定蛋白磷酸酶在正常和病理条件下的不同功能方面正在取得快速进展，所述正常和病理条件例如糖尿病、癌症、神经变性条件、发育和免疫缺陷以及心血管疾病。