MOLECULAR BIOLOGY OF MUSCLE DEVELOPMENT AND DIS

描述（摘自申请人摘要）：这是一项召集 一个关于"肌肉发育的分子生物学和， 疾病"将在太平洋格罗夫的阿西洛马会议中心举行， 2000年5月21日至26日在加州举行。会议的重点是归纳和 调节脊椎动物和无脊椎动物的肌肉发生，神经肌肉 相互作用和骨骼肌疾病。骨骼肌领域 分子生物学在过去的几年里经历了巨大的进步， 年，包括转录因子和信号转导的鉴定 在早期骨骼肌形成过程中， 发育，将这种组织模式化为不同类型的信号， 肌肉组织，控制增殖和分化的因素， 骨骼肌，调节突触特异性基因表达的信号， 控制神经肌肉接头的形成。此外，最后 十年来，我们在分子生物学的理解上取得了重大进展， 许多肌肉病理，包括：杜兴肌营养不良症， 肢带型肌营养不良，Freidrich共济失调，肌萎缩侧索硬化 硬化症、强直性肌营养不良和近端脊髓性肌萎缩。这 会议将包括世界各国专家在每一个这些 领域的这次会议是独一无二的肌肉生物学社区带来 一起研究肌肉生物学和胚胎学的研究人员 脊椎动物和无脊椎动物系统的发展， 疾病中的肌肉病理该会议已有20年历史， 以前作为Keystone研讨会举行，每三年召开一次。他们 我已经改变了今年的地点阿西洛马，并预计，在 过去的会议，他们将吸引来自世界各地的400 - 500名与会者， 地球仪。

DESCRIPTION (Taken from the applicants abstract): This is a proposal to convene an international meeting on "Molecular Biology of Muscle Development an, Disease" to be held at the Asilomar Conference Center in Pacific Grove, California from May 21-26, 2000. The conference focuses on the induction and regulation of myogenesis in both vertebrates and invertebrates, nerve muscle interactions, and diseases of skeletal muscle. The field of skeletal muscle molecular biology has undergone enormous advances within the past several years, including the identification of transcription factors and signaling molecules that control the formation of skeletal muscle during early development, the signals that pattern this tissue into different types of musculature, the factors that control the proliferation and differentiation of skeletal muscle, the signals that regulate synapse-specific gene expression and control the formation of the neuromuscular junction. Furthermore, the last decade has seen significant advances in our understanding the molecular biology of a number of muscle pathologies, including: Duchene muscular dystrophy, Limb-Girdle muscular dystrophy, Freidrich's Ataxia, Amyotrophic Lateral Sclerosis, Myotonic Dystrophy, and proximal spinal muscular atrophy. This conference will include presentations by the world's experts in each of these fields. This conference is unique in the muscle biology community at bringing together investigators studying the biology and embryology of muscle development in both vertebrate and invertebrate systems with those studying muscle pathology in disease. This conference has a 20 year history and has previously been held as a Keystone symposium, convening every three years. They have changed the venue this coming year to Asilomar, and anticipate that as in past conferences they will attract between 400-500 participants from around the globe.