Developmental Vitamin D-deficiency and Autism; exploration of potential mechanisms and refining phenotype in an animal model

发育性维生素 D 缺乏症和自闭症；

• 批准号: nhmrc : 1141699
• 负责人: Prof Andrew Whitehouse
• 金额: $ 29.9万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/developmental-vitamin-d-animal-model/1319542
• 关键词: Developmental; Vitamin; deficiency; Autism; exploration

We have now shown in a large cross-sectional study that low levels of vitamin D during gestation increase the incidence of autism in children. When we model this risk-relationship in animals we show changes in important developmental processes and behaviours previously linked to autism in children. We now want to understand both the exact downstream molecular pathways affected in the developing brain along with the precise brain structural and behavioural abnormalities produced in offspring.

我们现在已经在一项大型横断面研究中表明，怀孕期间维生素D水平低会增加儿童自闭症的发病率。当我们在动物中建立这种风险关系的模型时，我们发现了以前与儿童自闭症相关的重要发育过程和行为的变化。我们现在想了解在发育中的大脑中受到影响的确切下游分子通路沿着在后代中产生的精确大脑结构和行为异常。