AGING EFFECTS ON CARDIOVASCULAR FUNCTION

衰老对心血管功能的影响

• 批准号: 6169601
• 负责人: STEPHEN F VATNER
• 金额: $ 35.23万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6169601
• 关键词: Anthropoidea; adrenergic receptor; age difference; aging; animal old age; biological signal transduction; cardiovascular function; cardiovascular pharmacology; disease /disorder model; echocardiography; heart conduction system; histology; neural information processing; norepinephrine; vasomotion

DESCRIPTION (adapted from the applicant's abstract): Three defects which have been observed with aging are increased vascular stiffness, depressed responsiveness to catecholamines, and depressed cardiac function. Derangements in adrenergic signaling may presage dysfunction in the cardiac and vascular systems that is induced by the aging process. There are three major components to this study: 1) that altered adrenergic control of vasoactivity precedes increased stiffness in the aged vasculature; 2) that altered adrenergic control of left ventricular (LV) function presages the decline in LV function in the aged heart; and 3) that changes in cardiac and vascular structure in the aging heart are responsible for altered vascular and LV function, but these changes are not necessary for altered adrenergic signaling. To address these components the alterations in arterial pressure/dimension relations, LV function and altered adrenergic signaling with aging will be determined in conscious, chronically instrumented monkeys. The alterations in aging at the cellular and molecular level and histologic alterations in cardiac and vascular structure will be examined. These studies will be conducted in 4 groups of monkeys: 1) younger adults (3-5 years); 2) mature adults (7-10 years); 3) older adults (15-19 years); and 4) senescent adults (older that 20 years).

描述（改编自申请人的摘要）：三个缺陷 据观察，随着年龄的增长，血管僵硬度增加， 对儿茶酚胺的反应性和心脏功能下降。 肾上腺素能信号紊乱可能预示着心脏功能障碍 和由衰老过程引起的血管系统。 有三个 本研究的主要组成部分：1）改变肾上腺素能控制 血管活性先于老化血管系统的僵硬增加； 2）那个 左心室（LV）功能的肾上腺素能控制的改变预示着 老年心脏左心室功能下降； 3）心脏的变化 衰老心脏中的血管结构是造成血管改变的原因 和左心室功能，但这些改变对于改变肾上腺素能来说不是必需的 发信号。 为了解决这些问题，需要改变动脉 压力/尺寸关系、左心室功能和肾上腺素信号传导改变 随着年龄的增长，将由有意识的、长期的仪器决定 猴子。 细胞和分子水平上的衰老变化 将检查心脏和血管结构的组织学改变。 这些研究将在 4 组猴子中进行：1) 年轻的成年猴子 （3-5年）； 2）成熟的成年人（7-10岁）； 3）老年人（15-19岁）； 4) 老年人（20 岁以上）。