TRAINING IN INVESTIGATIVE AND MOLECULAR DERMATOLOGY

描述(来自申请表)：这项申请是1991年在凯斯西储大学(CWRU)建立的研究和分子皮肤病培训计划的竞争性更新。该计划的主要目标是为高素质的年轻研究人员提供在调查皮肤病学和皮肤生物学方面进行最先进的跨学科研究培训的机会。符合条件的候选人包括具有至少两年皮肤病学临床培训的内科医生(医学博士S)和具有最多两年博士后工作经验的基础科学家(博士S)，他们都明确致力于皮肤病学研究或基础皮肤生物学的学术生涯。针对以下四个研究领域之一的学员制定了个性化的职业发展计划，每个研究领域都与皮肤的生理学和病理学有关：免疫生物学、分子和细胞生物学、光皮肤病/光医学以及皮肤药理学/癌症发生学。每名研究员从这四个培训轨道中选择一个，由一名主任和一名联席主任以及参与培训的教职员工监督，他们是该领域国内和国际公认的领导者，拥有外部资助的研究计划，并是该学科的公认培训者。通过这种专注而又互动的机制，学员被教导如何科学地处理皮肤生物学中的问题，并有机会获得现代研究方法和使用尖端设备的经验。每个研究员都被提供了一套连贯的实验的设计和执行方面的指导，这些实验解决了具体的假设。每两周举行一次正式讨论，强调对结果进行伦理分析和公布。除了实验室培训外，研究员还参加课程、讲习班、研讨会和数据介绍练习，并被要求在科学会议上介绍他们的工作，包括皮肤病研究学会的年度会议。因此，通过集中参与重点研究项目和通过会议/研讨会进行培训，在这些会议/研讨会中实施基础科学研究以及将研究应用于临床问题。CWRU的17名培训教师有着出色的培训记录，他们的凝聚力在一位以研究为导向的皮肤病主席的领导下得到了加强。所有教员都是美国国立卫生研究院资助的皮肤病研究中心的活跃成员。CWRU的这个多学科中心为基础科学和临床部门之间的合作互动奠定了坚实的基础，并为考虑从事皮肤病学术生涯的年轻研究人员提供了理想的培训里程。

DESCRIPTION (from the application): This application is a competitive renewal of the Training Program in Investigative and Molecular Dermatology that was established in 1991 at Case Western Reserve University (CWRU). The major objective of this program is to provide highly qualified, young investigators with opportunities for state-of-the-art interdisciplinary research training in investigative dermatology and cutaneous biology. Eligible candidates include physicians (M.D.'s) with a minimum of two years of clinical dermatology training and basic scientists (Ph.D.'s) with up to two years of postdoctoral experience, both of whom have a definite commitment to an academic career in investigative dermatology or basic cutaneous biology. Individualized career building programs are developed for trainees in one of four research areas, each of which is related to the physiology and pathology of the skin: immunobiology, molecular and cellular biology, photodermatology/photomedicine, and skin pharmacology/carcinogenesis. Each fellow selects one of these four training tracks, which is supervised by a Director and a Co- Director and participating faculty members who are nationally and internationally recognized leaders in that field and who have extramurally funded research programs and are recognized trainers in that discipline. Through this focused, yet interactive mechanism, the trainees are taught how to scientifically approach problems in cutaneous biology and are given the opportunity to gain experience in modern research methodology and in the use of sophisticated equipment. Each fellow is provided guidance in the design and performance of a coherent set of experiments which addresses specific hypotheses. A biweekly formal discussion emphasizes the ethical analysis and publication of results. In addition to laboratory training, the fellows participate in courses, workshops, symposia and data presentation exercises and are required to present their work at scientific meetings including the annual meeting of the Society for Investigative Dermatology. Thus, training occurs through intensive participation in a focused research project and through conferences/seminars in which the basic science research, as well as the application of research to clinical problems are implemented. The seventeen CWRU training faculty have an excellent training record, and their cohesiveness is strengthened by the leadership of a research-oriented Dermatology Chairman. All faculty are active members of the NIH- funded Skin Diseases Research Center. This multidisciplinary Center at CWRU has created a strong foundation for cooperative interactions between basic science and clinical departments and provides an ideal training mileau for young investigators contemplating a career in academic dermatology.