课题基金 / 基金详情

POLYMORPHIC UPSTREAM STRUCTURE & PFG 27/25 GENE CONTROL

POLYMORPHIC UPSTREAM STRUCTURE & PFG 27/25 GENE CONTROL
多态上游结构
批准号：
6170096
负责人：
Ute Frevert
金额：
$33.65万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-05-01 至 2002-04-30
来源：
https://reporter.nih.gov/project-details/6170096
关键词：
Plasmodium falciparum developmental genetics gene expression genetic mapping genetic polymorphism genetic transcription microorganism culture microorganism genetics nucleic acid hybridization nucleic acid probes nucleic acid sequence polymerase chain reaction protein structure pulsed field gel electrophoresis regulatory gene sex differentiation southern blotting transfection

项目摘要

项目成果

Ute Frevert的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
DESCRIPTION (Adapted from the Applicant's Abstract): The Plasmodium falciparum very early gametocyte stage gene, Pfg27/25, has a polymorphic locus upstreasm of the coding sequences which is surrounded by conserved sequences. The structure of the polymorphic region specifies accurate or altered blood stage specific transcription of the gene. The polymorphic structures arise by an as yet uncharacterizes DNA rearrangement. The overall objectives of this proposal are to determine the detailed structure of this locus in laboratory isolates that display different blood satge specific transcription patterns for the Pfg17/25 gene, and the extent to which these polymorphisms occur in nature. The 5' terminus of the Pfg27/25 mRNAs will also be determined to see where the transcription start sites occur with respect to the boundaries of the polymorphic domain.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Development of a topical malaria vaccine.
The Lung and Malaria
The Lung and Malaria
Imaging preerythrocytic Plasmodium stages in naive and immune individuals
海外基金