NEW HIGHLY EFFICIENT ROUTES TO POLYKETIDES

描述：（主要研究者）本项目的目标是 开发廉价的方法来制造大量有用的药物。 的 作为该项目重点的特殊化合物类别是 聚酮化合物。 这些分子广泛用于临床实践， 特别是作为抗生素。 例如，红霉素是一种复合物 聚酮化合物已被广泛用作抗生素，因为它能够 在不影响人类的情况下杀死细菌 医生使用其他聚酮化合物 作为抗病毒剂、抗真菌剂、抗癌剂和免疫抑制剂。 虽然确实存在合成聚酮化合物的方法， 本提案中所述的方法更适用于工业用途， 现有的。 最重要的是， 与现有方法的不同之处在于使用催化反应， 准备起始材料。 只有非常少量的催化剂被 所提出的方法中所需的，并且很可能催化剂将是 一次又一次地重复使用。 所提出的化学方法的另一个优点是 许多步骤可以在相同的反应溶剂和反应器中进行。 这种性质对于工业合成非常重要，因为每增加一个 溶剂和反应器的使用增加了废物的量和反应器的复杂性。 过程

DESCRIPTION: (Principal Investigator's) The goal of this project is to develop inexpensive methods for making large amounts of useful drugs. The particular class of compounds that are the focus of this project are the polyketides. These molecules are widely used in clinical practice, particularly as antibiotics. For example, erythromycin is a complex polyketide that has found wide use as an antibiotic, because of its ability to kill bacteria without affecting humans. Physicians use other polyketides as antiviral, antifungal, anticancer and immunosuppressive agents. Although methods do exist for the synthesis of polyketides, the methods described in this proposal are much more applicable to industrial use than existing ones. The most important way in which the proposed chemistry differs from current methods is in the use of a catalytic reaction to prepare the starting materials. Only very small amounts of the catalyst are required in the proposed methods, and it is likely that the catalyst will be reused time and time again. Another advantage of the proposed chemistry is that a number of steps can be run in the same reaction solvent and reactor. This property is very important for industrial syntheses, as each additional solvent and reactor increases the amount of waste and complexity of the process.