NEW HIGHLY EFFICIENT ROUTES TO POLYKETIDES

描述：(首席调查员)这个项目的目标是 开发廉价的方法来制造大量有用的药物。这个 这一项目的重点是特定类别的化合物 聚酮类化合物。这些分子在临床实践中被广泛使用， 尤其是作为抗生素。例如，红霉素是一种复合体 一种广泛用作抗生素的聚酮，因为它的能力 在不影响人类的情况下杀死细菌。内科医生使用其他聚酮 作为抗病毒、抗真菌、抗癌和免疫抑制药物。 虽然确实存在合成聚酮的方法，但这些方法 本提案中描述的更适用于工业用途，而不是 现有的。提出的化学最重要的方式是 与当前方法的不同之处在于使用催化反应来 准备开始的材料。只有极少量的催化剂 在提议的方法中需要，并且很可能催化剂将是 一次又一次地重复使用。所提议的化学的另一个优点是 可以在相同的反应溶剂和反应器中进行多个步骤。 这一性质对工业合成非常重要，因为每增加一个 溶剂和反应器增加了废物量和复杂性 进程。

DESCRIPTION: (Principal Investigator's) The goal of this project is to develop inexpensive methods for making large amounts of useful drugs. The particular class of compounds that are the focus of this project are the polyketides. These molecules are widely used in clinical practice, particularly as antibiotics. For example, erythromycin is a complex polyketide that has found wide use as an antibiotic, because of its ability to kill bacteria without affecting humans. Physicians use other polyketides as antiviral, antifungal, anticancer and immunosuppressive agents. Although methods do exist for the synthesis of polyketides, the methods described in this proposal are much more applicable to industrial use than existing ones. The most important way in which the proposed chemistry differs from current methods is in the use of a catalytic reaction to prepare the starting materials. Only very small amounts of the catalyst are required in the proposed methods, and it is likely that the catalyst will be reused time and time again. Another advantage of the proposed chemistry is that a number of steps can be run in the same reaction solvent and reactor. This property is very important for industrial syntheses, as each additional solvent and reactor increases the amount of waste and complexity of the process.