课题基金 / 基金详情

TGF-B RECEPTOR ALTERATIONS AND PANCREAS CANCER

TGF-B RECEPTOR ALTERATIONS AND PANCREAS CANCER
TGF-B 受体改变与胰腺癌
批准号：
6172812
负责人：
James W. Freeman
金额：
$22.44万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-08-01 至 2002-08-31
来源：
https://reporter.nih.gov/project-details/6172812
关键词：
athymic mouse gene induction /repression growth factor receptors guanine nucleotide binding protein human genetic material tag human tissue mutant neoplasm /cancer genetics neoplastic process nucleic acid sequence pancreas neoplasms protein structure function receptor expression transforming growth factors tumor suppressor genes

项目摘要

项目成果

James W. Freeman的其他基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
DESCRIPTION: The long term goal of this study is to determine the role of TGFbeta RII receptor (RII) in pancreatic cancer. Loss of response to TGFbeta appears common to pancreatic cancer, which is often caused by a loss of the RII gene expression. The hypothesis to be tested in this revised application is that the loss of RII expression is caused by ras-mediated down regulation of the gene and that lack of a functional RII receptor plays an important role in the tumorigenic properties of pancreatic cancers. The specific aims are 1) Determine the mechanism by which oncogenic ras inhibits RII expression and/or causes resistance to growth inhibition by TGFbeta, and 2) Determine the biological role of RII in tumor progression in ras-mutated pancreatic cancer cells.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Role of CD44 in adaptive plasticity of pancreatic cancer
Role of CD44 in adaptive plasticity of pancreatic cancer
Role of Ron kinase in pancreatic cancer
Role of Ron kinase in pancreatic cancer