COMPUTER EDUCATION FOR BREAST CANCER GENETIC TESTING

乳腺癌基因检测的计算机教育

• 批准号: 6175315
• 负责人: Michael J. Green
• 金额: $ 22.36万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6175315
• 关键词: DVD /CD ROM; breast neoplasms; cancer risk; clinical research; clinical trials; computer assisted diagnosis; computer assisted medical decision making; computer human interaction; female; genetic counseling; genetic disorder diagnosis; genetic screening; human subject; neoplasm /cancer education; questionnaires; women's health

The long term goal of this project is to improve patient understanding about breast cancer risk and genetic testing. We have previously developed a patient-oriented CD-ROM called "Counseling by Computer: Breast Cancer Risk and Genetic Testing ." The proposed research is to conduct a clinical trial to evaluate the effectiveness of the CD-ROM at educating women about breast cancer risk, and options and implications of genetic testing. This project will take 36 months to complete and involves two specific aims: Specific Aim 1: to evaluate the effectiveness of our CD-ROM at educating women about breast cancer risk, and the options and implications of genetic testing. We will complete this aim in two phases. During phase 1 we will obtain critical feedback on the CD-ROM and survey instruments from a diverse group of women in Central Pennsylvania. Forty women (at least 1/4 of whom are minorities) will be recruited from a general internal medicine clinic and breast cancer support group to evaluate the useability and effectiveness of the CD-ROM. The survey data will be used to refine the CD-ROM and study instruments in preparation for a randomized trial. Phase 2 will be to evaluate the impact of the CD-ROM on those actually considering genetic testing for breast cancer susceptibility, through a randomized, pretest-posttest control-group, crossover trial of 210 patients at three study sites. The effectiveness of computer-based education will be compared with one-on-one education for the impact on patients': risk perception; intent to receive genetic testing; knowledge about breast cancer risk and genetic testing; satisfaction with their decision about genetic testing; and decisional conflict. An assessment of the acceptability of each educational intervention will also be obtained. Specific Aim 2: to evaluate the impact of a prior computer-based educational session on subsequent interactions between patients and genetic counselors. As part of the randomized trial, we will study whether the addition of a computer-based educational program improves the interactions between patients and genetic counselors. Comparisons will be made between those educated by a genetic counselor alone, and those educated by a computer prior to their session with a genetic counselor, by measuring: the amount of time spent with a genetic counselor; the quality and quantity of questions directed to the genetic counselor; patient's and genetic counselor's satisfaction; and perceived effectiveness of the counseling session.

该项目的长期目标是提高患者对乳腺癌风险和基因检测的了解。 我们以前开发了一个面向病人的光盘，名为“计算机咨询：乳腺癌风险和基因检测”。“拟议的研究是进行一项临床试验，以评估光盘在教育妇女乳腺癌风险方面的有效性，以及基因检测的选择和影响。 该项目将需要36个月完成，涉及两个具体目标：具体目标1：评估我们的光盘在教育妇女了解乳腺癌风险方面的有效性，以及基因检测的选择和影响。我们将分两个阶段完成这一目标。 在第一阶段，我们将从宾夕法尼亚州中部的不同妇女群体那里获得关于光盘和调查工具的重要反馈。 将从普通内科诊所和乳腺癌支持小组招募40名妇女（其中至少四分之一是少数民族），以评估光盘的可用性和有效性。调查数据将用于改进光盘和研究工具，为随机试验做准备。 第二阶段将通过在三个研究中心对210名患者进行随机、前测-后测对照组、交叉试验，评估光盘对那些实际考虑进行乳腺癌易感性基因检测的患者的影响。 基于计算机的教育的有效性将与一对一的教育对患者的影响进行比较：风险认知;接受基因检测的意图;有关乳腺癌风险和基因检测的知识;对基因检测决定的满意度;以及决策冲突。 还将对每项教育干预措施的可接受性进行评估。 具体目标二：评估先前的基于计算机的教育会话对患者和遗传咨询师之间随后的互动的影响。 作为随机试验的一部分，我们将研究增加基于计算机的教育程序是否会改善患者和遗传咨询师之间的互动。 比较将由遗传咨询师单独教育的那些人，和那些在与遗传咨询师进行会话之前由计算机教育的人，通过测量：与遗传咨询师花费的时间量;针对遗传咨询师的问题的质量和数量;患者和遗传咨询师的满意度;以及咨询会话的感知效果。