COORDINATED CONTROL OF HPV TRANSCRIPTION AND REPLICATION

描述：（改编自研究者摘要）：在此修订的新 一位年轻的独立研究者提出申请，进行了一系列生物物理研究 研究提出了调查的机制，假设 乳头瘤病毒转录与DNA协同调控 复制的PI，亚历山大博士，假设这个坐标 调节是细胞转录和转录之间竞争的结果。 复制因子和病毒E1和E2蛋白， 有助于转录和复制。这项建议的目的是 评估这些因素对彼此DNA结合、蛋白质 结合和酶活性。将使用本研究获得的数据 建立HPV转录和复制控制的动态模型， 将广泛应用于DNA的转录和复制控制 病毒

DESCRIPTION: (Adapted from the Investigator's abstract): In this revised new application from a young independent investigator, a series of biophysical studies are proposed to investigate the mechanisms underlying the hypothesized coordinate regulation of papillomaviral transcription and papillomaviral DNA replication. The PI, Dr. Alexander, hypothesizes that this coordinate regulation is a consequence of competition between cellular transcription and replication factors and the viral E1 and E2 protein that regulate and contribute to transcription and replication. The aims of this proposal are to evaluate the influence of these factors on each other's DNA binding, protein binding and enzymatic activities. The data gained from this study will be used to create a dynamic model of HPV transcription and replication control that will be broadly applicable to transcription and replication control in DNA viruses.