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CATALYTIC SITE IN FURANOCOUMARIN-METABOLIC P450S

CATALYTIC SITE IN FURANOCOUMARIN-METABOLIC P450S
呋喃香豆素代谢 P450S 中的催化位点
批准号：
6180373
负责人：
Mary A Schuler
金额：
$27.08万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
项目状态：
已结题
起止时间：
1994-12-01 至 2003-01-31
来源：
https://reporter.nih.gov/project-details/6180373
关键词：
Lepidoptera active sites alleles chemical models chemical structure function cytochrome P450 cytotoxicity detoxification enzyme activity enzyme substrate furocoumarin isozymes mass spectrometry molecular cloning nuclear magnetic resonance spectroscopy photoactivation polymerase chain reaction tissue /cell culture

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DESCRIPTION (Adapted from the Applicant's Abstract): Furanocoumarins are naturally occurring plant metabolites that are extremely toxic because they react with pyrimidine bases in DNA and with general cellular proteins when photoactivated and because they interact reversibly and irreversibly with P450 catalytic sites. These photobiologic properties of furanocoumarins have been exploited for the treatment of a variety of human skin diseases even though the mechanisms for their metabolism and their effects on endogenous drug metabolizing P450s have not been well established. Much can be learned about their metabolism and mechanism of P450 inhibition by studying the P450s that are in herbivorous insects specialized to feed on host plants containing high levels of liner and angular forms of these furanocoumarins.
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Integrated Theoretical and Experimental Studies of P450 Structure and Function
Integrated Theoretical and Experimental Studies of P450 Structure and Function
Integrated Theoretical and Experimental Studies of P450 Structure and Function
Integrated Theoretical and Experimental Studies of P450 Structure and Function
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