REGULATION OF ASYMMETRIC FLAGELLAR WAVEFORMS

研究人员的目标是了解这一机制和规则 鞭毛的运动性。他们利用了权势集团 衣藻中可用的遗传工具，加上新开发的 通过插入突变标记和克隆基因的技术，开始 中心配对络合物功能的分子解剖 鞭毛轴丝。具体目标是：1)克隆和鉴定 中枢器官组件的额外基因；2)鉴定 与中央器官组件相互作用的蛋白质；3) 定义装配和功能所需的功能域 使用体外诱变的单个中央器官组件。这个 Amramdillo重复蛋白PF16，将作为第一靶点进行详细说明 分子分析。调查员表示，对中央的研究 设备部件不仅会对 鞭毛运动，也在运动调节和运动领域 微管功能。

The investigator's goal is to understand the mechanism and regulation of flagellar motility. They have taken advantage of the powerful genetic tools available in Chlamydomonas, coupled with newly developed techniques to tag and clone genes by insertional mutagenesis, to begin a molecular dissection of function of the central pair complex of the flagellar axoneme. The specific aims are: 1) to clone and characterize additional genes for central apparatus components; 2) to identify proteins interacting with components of the central apparatus; 3) to define functional domains required for assembly and function of individual central apparatus components using in vitro mutagenesis. The amramdillo repeat protein PF16, will be the first target for detailed molecular analysis. The investigator states that the study of central apparatus components will not only have an impact on the field of flagellar motility but also on the fields of motor regulation and microtubule function.