COGNITIVE EVENT-RELATED POTENTIALS AND BRAIN MATURATION

大脑额叶的成熟可能起着重要作用。 在发展信息处理能力方面。脑电记录 和事件相关电位(ERPs)允许检查区域 特定信息加工执行过程中的大脑活动 任务。本研究计划的目标是：1)建立 青春期发育的电生理标志物；以及2) 将电生理数据与认知能力的变化联系起来 发生在青春期。这一过程将使我们能够将区域大脑联系起来 从电生理数据到行为的发展 随着年龄的变化而变化。三个假设将被检验：1)ERP模式 它们反映了特定的认知功能 不同年龄段的受试者；2)与后部相关的事件相关电位 会在比事件相关电位更年轻的时候表现出成人的特征 与大脑额叶区域相关；以及3)事件相关电位数据将 与行为任务的表现相关。这些假设将是 通过检查儿童和幼儿时记录的ERP组件进行测试 成年人执行特定的信息处理任务。 这一指导研究科学家奖的教育目标是： 1)PI将扩大研究技能，扩大研究网络。希德博士 Segalowitz将在实验室担任这一经历的导师。这个 PI将参加强化实验室经验的课程。2) 推进PI的研究意愿，开发新的研究项目，解决 康复中的临床干预。这将通过以下方式实现 研究计划的完成和试点研究的启动 这将研究残疾儿童的事件相关电位模式。3)推广 具有传播研究成果和实验室管理的技能。 PI将为同行评议的期刊准备稿件，报道 这些研究的结果，并指导研究生在相关的 研究项目。

The maturation of the frontal lobe of the brain may play an important role in the development of information processing abilities. Recordings of EEG and event-related potentials (ERPs) permit the examination of regional brain activity during the performance of specific information processing tasks. The goals of this research plan are: 1) to establish electrophysiological markers of development through adolescence; and 2) to relate the electrophysiological data to cognitive performance changes that occur in adolescence. This process will allow us to relate regional brain development as reflected in electrophysiological data to behavioral changes across ages. Three hypotheses are to be examined: 1) ERP patterns that are reflective of specific cognitive functioning will vary for participants of different ages; 2) ERPs associated with posterior regions of the brain will manifest adult properties at a younger age than ERPs associated with frontal regions of the brain; and 3) the ERP data will correlate with performance on behavioral tasks. These hypothesis will be tested by examining ERP components recorded while children and young adults perform specific information processing tasks. The educational objectives of this mentored research scientist award are: 1) The PI will expand research skills and extend research network. Dr. Sid Segalowitz will serve as mentor for this experience in the laboratory. The PI will attend courses that reinforce the laboratory experience. 2) Advance research wills of PI and develop new research projects addressing clinical intervention in rehabilitation. This will be accomplished through the completion of the research plan and the initiation of pilot studies that will examine ERP patterns in children with disabilities. 3) Promote skills in the dissemination of research results and laboratory management. The PI will prepare manuscripts for peer reviewed journals reporting the results of these studies and supervise graduate students in related research projects.