AGING, EXERCISE AND ENDOTHELIAL FUNCTION

描述 (改编自申请人摘要)申请人Christopher A.DeSouza， 博士，生理学家，目前拥有非终身教职 科罗拉多大学运动学系的任命。 德索扎博士在学术工作方面表现出一贯的专注和记录。 在体力活动、衰老和心血管疾病风险方面 各种因素。他的职业目标是发展一个独立的、由外部资金资助的 研究实验室，其使命是：1)研究物理 与人类健康、疾病和衰老有关的活动；2) 科学培养本科生、研究生和博士后 伙计们。少数民族导师研究科学家发展奖 教员将提供研究和职业发展计划。这个 研究和职业发展计划由两个主要要素组成：1) 获得大量新的研究技能；以及2) 有组织的活动，包括正式课程--研究伦理和 生物统计学.参加期刊俱乐部和系列研讨会.常规 指导互动；以及出席科学会议。此外 给赞助商，以及资深调查人员咨询委员会 以及在拟议研究的所有方面都有专业知识的教职员工 并制定了职业发展计划，为德索萨博士提供指导。 研究计划。研究项目的总体目标是确定 在体力活动中内皮功能是否随着年龄的增长而下降 以及规律的有氧运动计划是否能恢复 部分，如果不是全部，内皮功能的丧失在中年和 久坐不动的老年人。一般的假设是内皮功能 在体力活动人群中不会随着年龄的增长而下降 有氧运动可增强中老年人血管内皮功能 久坐不动的成年人。支持这一假说的结果将提供新的和 对倡导规律的生理和临床有帮助的见解 有氧运动作为治疗原发性和继发性疾病的一种策略 预防年龄相关性内皮功能障碍。 环境德苏扎博士接受培训的环境非常好。 发起人道格拉斯·R·西尔斯博士是一位知名的研究人员， 在心血管综合研究方面的导师，并拥有资金雄厚的 实验室。他和东道主部门将为DeSouza博士提供所有 成功完成训练所需的资源。(末尾 摘要)

DESCRIPTION (Adapted from applicant's abstract) The applicant, Christopher A. DeSouza, Ph.D., is a physiologist currently holding a non-tenure track faculty appointment in the Department of Kinesiology at the University of Colorado. Dr. DeSouza has demonstrated a consistent focus and record of scholarly work in the area of physical activity, aging, and cardiovascular disease risk factors. His career goal is to develop an independent extramurally-funded research laboratory which has as its mission: 1) the study of physical activity as it pertains to human health, disease, and aging; and, 2) the scientific training of undergraduate and graduate students, and postdoctoral fellows. The Mentored Research Scientist Development Award for Minority Faculty would provide the Research and Career Development Plan. The research and career development plan consists of 2 primary elements: 1) the acquisition of an impressive number of new research skills; and 2) structured activities including formal course-work in research ethics and biostatistics; participation in journal clubs and seminar series; regular mentoring interactions; and attendance at scientific meetings. In addition to the sponsor, and advisory committee of established senior investigators and faculty members with expertise in all aspects of the proposed research and career development plan has been formed to mentor Dr. DeSouza. Research Plan. The general aim of the research project is to determine whether endothelial function declines with age in physically active populations and whether a program of regular aerobic exercise can restore some, if not all, of the loss in endothelial function in middle-aged and older sedentary adults. The general hypothesis is that endothelial function does not decline with age in physically active populations and that regular aerobic exercise can enhance endothelial function in middle-aged and older sedentary adults. Results supporting this hypothesis would provide new and useful physiological and clinical insight into the advocacy of regular aerobic exercise as a therapeutic strategy for both primary and secondary prevention of age-related endothelial dysfunction. Environment. The environment for Dr. DeSouza's training is outstanding. The sponsor, Douglas R. Seals, Ph.D., is an established investigator and mentor in integrative cardiovascular research, and has a well-funded laboratory. He and the host department will provide Dr. DeSouza all of the necessary resources to successfully complete his training. (End of Abstract)