Discovering Optimal Weight Loss Interventions to Prevent Osteoarthritis in Obesity Through the Lens of Early Biomarkers: the TANGO Diet Trial

通过早期生物标志物发现预防肥胖症骨关节炎的最佳减肥干预措施：TANGO 饮食试验

• 批准号: nhmrc : 1143022
• 金额: $ 21.82万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/discovering-optimal-weight-diet-trial/1319854
• 关键词: Discovering; Optimal; Weight; Loss; Interventions

Osteoarthritis (OA) is the most common type of arthritis, and an obese population increases the disease burden of OA. Weight-loss is the first line management for symptom relief but is unclear whether weight loss can prevent OA changes in the joint. Biological OA markers can pick up early disease changes long before any signs on routine X-ray. My research will look at the effect of weight loss by very low energy diet on early OA biomarker in patients with overweight or obesity.

骨关节炎(OA)是最常见的关节炎类型，肥胖人口增加了OA的疾病负担。减肥是缓解症状的一线治疗方法，但目前尚不清楚减肥是否能防止关节骨关节炎的改变。生物OA标记物可以在常规X光检查出现任何征兆之前很久就发现疾病的早期变化。我的研究将着眼于通过极低能量饮食减肥对超重或肥胖患者早期骨性关节炎生物标志物的影响。