EFFECT CA++ FOODS ON BONE QUALITY IN PUBERTAL FEMALES

CA 食物对青春期女性骨骼质量的影响

• 批准号: 6186853
• 负责人: JOAN LAPPE
• 金额: $ 10.6万
• 依托单位: CREIGHTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6186853
• 关键词: adolescence (12-20); body physical activity; bone density; bone development; clinical research; densitometry; developmental nutrition; diet therapy; dietary calcium; disease /disorder prevention /control; female; human puberty; human subject; human therapy evaluation; longitudinal human study; middle childhood (6-11); nursing intervention; nutrient intake activity; nutrition related tag

DESCRIPTION (Adapted from the Investigator's Abstract): Osteoporosis is a major public health concern. The application focuses on the problem early in life. Since there are no known safe, effective methods for restoring lost bone to the osteoporotic skeleton, prevention of osteoporosis is crucial. If skeletal development can be maximized during growth, young people will begin adulthood with optimal bone quality and be less likely to develop osteoporosis in later years. Yet bone health of children has not been adequately addressed. This proposal will build on 3 previous studies of bone quality in children. The aim of this experimental study is to test the effect of increasing dietary calcium intake to 1500 mg/day on increases in bone quality in pubertal females at age nine. The hypothesis to be tested is: pubertal females who consume a high calcium diet will have a greater increase bone quality, as measured by densitometry and ultrasound, than pubertal females who consume their usual dietary calcium intake. A convenience sample of 60 nine year old females will be randomly assigned to a treatment group given high calcium foods supplying 1500 mg/day for 4 years or a control group consuming their usual dietary calcium intake. Measurements of bone quality, bone mass, physical activity, dietary intake, height, weight, Tanner Stage, and medical history will be made at baseline, every three months, and at the end of the study. Evidence of a positive effect of increased calcium intake from food sources on bone quality in pubertal females will be followed by another proposal to determine if this treatment cohort can maintain their skeletal advantage into late adolescence. The overall long-term aim of the P.I.'s work is to test interventions designed to bring about conscious increase in calcium intake and physical activity in children that will improve their bone health and help to develop lifelong bone healthy behaviors.

描述（改编自研究者摘要）：骨质疏松症是一种 重大公共卫生问题。 应用程序及早关注问题 生活中 由于没有已知的安全、有效的方法来恢复 骨质疏松症的预防方法有哪些？ 至关重要的. 如果骨骼发育在生长过程中能够最大化， 人们将开始具有最佳骨质的成年期， 在晚年患上骨质疏松症。 然而，儿童的骨骼健康并没有 得到了充分的处理。 该建议将建立在3个以前的研究基础上 儿童的骨质。 本实验研究的目的是测试 增加膳食钙摄入量至1500毫克/天对增加 9岁青春期女性的骨质 假设是 测试是：青春期女性谁消耗高钙饮食将有一个 更大的增加骨质量，通过密度测定和超声测量， 而青春期的女性通常只摄入钙。 一 将60名9岁女性的方便样本随机分配至 治疗组给予高钙食物，每天补充1500 mg，连续4年 或对照组消耗他们通常的膳食钙摄入量。 测量骨质量、骨量、体力活动、饮食摄入量， 将在基线时记录身高、体重、坦纳分期和病史， 每三个月一次，研究结束时。 积极的证据 增加食物来源钙摄入对骨质量的影响 青春期女性将遵循另一项建议，以确定这是否 治疗队列可以保持他们的骨骼优势， 青春期 P.I.的总体长期目标。的工作是测试 旨在有意识地增加钙摄入量的干预措施 和体力活动，这将改善他们的骨骼健康， 有助于养成终身骨骼健康行为。