NMR AND MR IMAGING STUDIES OF PLAQUE RUPTURE
NMR AND MR IMAGING STUDIES OF PLAQUE RUPTURE
批准号:
6013502
负责人:
JAMES Athur HAMILTON
金额:
$40.27万
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-08-08 至 2004-07-31
关键词:
aorta atherosclerosis atherosclerotic plaque bioimaging /biomedical imaging biomarker blood vessel occlusion body temperature calcium chemical property cholesterol cholesterol esters coronary occlusion /thrombosis disease /disorder model histochemistry /cytochemistry laboratory rabbit light microscopy lipid structure macrophage magnetic resonance imaging metalloendopeptidases morphology nuclear magnetic resonance spectroscopy physical property prognosis thromboplastin
中文摘要
虽然在检测和治疗方面取得了进展,
心血管疾病、心肌梗塞和中风常常发生
表面上健康的人在没有警告的情况下造成残疾或死亡。
动脉粥样硬化是大多数心脏病发作和中风的根本原因。
动脉粥样硬化斑块可以随着时间的推移缓慢增长,并逐渐阻塞血液
流动,经常产生警告患者潜在疾病的症状。
然而,较少闭塞的斑块可以在几分钟内产生急性事件,
破裂并突然形成闭塞性血栓。这些斑块似乎
具有某些物理特性,例如薄的纤维帽,
富含脂质的核心,这将它们与危险性较小的斑块区分开来。有
通过成像方法评估人类血管疾病的新紧迫性,
提供有关斑块超微结构的数据,而不是侵入性方法
例如仅报告管腔变窄血管造影术。此项目使用
改良Constantinides动物(兔)斑块破裂模型比较
未破裂斑块和破裂斑块的斑块成分和超微结构。
将对家兔(体内)主动脉进行磁共振(MR)成像,
在触发斑块破裂前后,
),在切除后。破裂型与非破裂型食管癌的MR图像比较
非破裂斑块将提供斑块破裂的标志物,并确定
磁共振成像预测易损斑块的价值将为
斑块破裂及MR成像预测易损斑块的价值
在破裂发生之前的人类斑块。魔角旋转(MAS)NMR
光谱学将用于原位表征每种脂质的组成
切下的斑块阶段。MAS NMR允许定量晶体
胆固醇、液体和液晶胆固醇酯和钙
完整菌斑中的盐;这些结构中的每一个单独或相互作用
在它们之间,可能在斑块脆弱性中起作用。增强
MR图像的解释,详细的物理化学信息,
MAS NMR将与脂质和蛋白质的空间信息相结合
通过磁共振(MR)成像和光
显微镜/组织学。因为斑块的超微结构似乎是
对于它们的稳定性和回归潜力,MR成像具有潜力
作为急性病理事件(心脏病发作)的更可靠的预测因子,
和中风)。
英文摘要
Although the advances have been made in the detection and treatment
of vascular diseases, myocardial infarctions and strokes often strike
apparently healthy persons without warning and produce disabilities or death.
Atherosclerosis is the underlying cause of most heart attacks and strokes.
Atherosclerotic plaques can grow slowly over time and gradually block blood
flow, often producing symptoms that warn the patient of the underlying disease.
However, less occlusive plaques can produce acute events within minutes by
rupturing and abruptly forming an occlusive thrombus. These plaques appear to
have certain physical characteristics, such as a thin fibrous cap and
lipid-rich core, which distinguish them from less dangerous plaques. There is
new urgency to evaluate vascular disease in humans by imaging methods that
provide data about the ultrastructure of plaques, rather than invasive methods
such as angiography that report only luminal narrowing. This project uses the
modified Constantinides animal (rabbit) model of plaque rupture to compare
plaque components and ultrastructure in non-ruptured and ruptured plaques.
Magnetic resonance (MR) images of the aorta in rabbits (in vivo) will be
obtained before and after triggering plaque rupture, and 9with higher
resolution) after excision. Comparison of the MR images of ruptured and
non-ruptured plaques will provide markers for plaque rupture and determine the
value of MR imaging for predicting vulnerable plaques will provide markers for
plaque rupture and determine the value of MR imaging for predicting vulnerable
plaques in humans before rupture occurs. Magic angle spinning (MAS) NMR
spectroscopy will be used to characterize in situ the composition of each lipid
phase in excised plaques. MAS NMR allows quantitation of crystalline
cholesterol, liquid and liquid-crystalline cholesteryl esters, and calcium
salts in the intact plaque; each of these structures alone, or interactions
between them, may play a role in plaque vulnerability. To enhance the
interpretation of MR images, the detailed physical chemical information from
MAS NMR will be integrated with the spatial information about lipid and protein
components determined by magnetic resonance (MR) imaging and light
microscopy/histology. Because the ultrastructure of plaques appears to be key
to their stability and potential for regression, MR imaging has the potential
for being a more reliable predictor of acute pathological events (heart attack
and stroke).
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Imaging the Vascular Consequences of Lipid Deposition
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批准号:7140908
-
项目类别:
-
资助金额:$65.18万
-
财政年份:2006
-
负责人:JAMES Athur HAMILTON
-
依托单位:
FATTY ACID TRANSPORT--STRUCTURAL AND CELL BIOLOGY
-
批准号:6847167
-
项目类别:
-
资助金额:$22.65万
-
财政年份:2004
-
负责人:JAMES Athur HAMILTON
-
依托单位:
Transport and Metabolism of Fatty Acids in Adipocytes
-
批准号:6320163
-
项目类别:
-
资助金额:$32.03万
-
财政年份:2001
-
负责人:JAMES Athur HAMILTON
-
依托单位:
Transport and Metabolism of Fatty Acids in Adipocytes
-
批准号:6638757
-
项目类别:
-
资助金额:$32.03万
-
财政年份:2001
-
负责人:JAMES Athur HAMILTON
-
依托单位:
Transport and Metabolism of Fatty Acids in Adipocytes
-
批准号:6537976
-
项目类别:
-
资助金额:$32.03万
-
财政年份:2001
-
负责人:JAMES Athur HAMILTON
-
依托单位:
Transport and Metabolism of Fatty Acids in Adipocytes
-
批准号:6727645
-
项目类别:
-
资助金额:$24.1万
-
财政年份:2001
-
负责人:JAMES Athur HAMILTON
-
依托单位:
FATTY ACID TRANSPORT--STRUCTURAL AND CELL BIOLOGY
-
批准号:6302138
-
项目类别:
-
资助金额:$34.7万
-
财政年份:2000
-
负责人:JAMES Athur HAMILTON
-
依托单位:
NMR AND MR IMAGING STUDIES OF PLAQUE RUPTURE
-
批准号:6642032
-
项目类别:
-
资助金额:$28.62万
-
财政年份:2000
-
负责人:JAMES Athur HAMILTON
-
依托单位:
TRANSPORT OF SULFONYL UREA DERIVATIVES BY TIME RESOLVED FLUORESCENCE METHODS
-
批准号:6345218
-
项目类别:
-
资助金额:$0.49万
-
财政年份:2000
-
负责人:JAMES Athur HAMILTON
-
依托单位:
NMR AND MR IMAGING STUDIES OF PLAQUE RUPTURE
-
批准号:6390183
-
项目类别:
-
资助金额:$26.98万
-
财政年份:2000
-
负责人:JAMES Athur HAMILTON
-
依托单位:
TRANSPORT OF SULFONYL UREA DERIVATIVES BY TIME RESOLVED FLUORESCENCE METHODS
-
批准号:6478942
-
项目类别:
-
资助金额:$5.36万
-
财政年份:2000
-
负责人:JAMES Athur HAMILTON
-
依托单位:
NMR AND MR IMAGING STUDIES OF PLAQUE RUPTURE
-
批准号:6527512
-
项目类别:
-
资助金额:$27.79万
-
财政年份:2000
-
负责人:JAMES Athur HAMILTON
-
依托单位:
FATTY ACID TRANSPORT--STRUCTURAL AND CELL BIOLOGY
-
批准号:6109586
-
项目类别:
-
资助金额:$34.7万
-
财政年份:1999
-
负责人:JAMES Athur HAMILTON
-
依托单位:
TRANSPORT OF SULFONYL UREA DERIVATIVES BY TIME RESOLVED FLUORESCENCE METHODS
-
批准号:6206413
-
项目类别:
-
资助金额:$0.49万
-
财政年份:1999
-
负责人:JAMES Athur HAMILTON
-
依托单位:
FATTY ACID TRANSPORT--STRUCTURAL AND CELL BIOLOGY
-
批准号:6272626
-
项目类别:
-
资助金额:$33.49万
-
财政年份:1998
-
负责人:JAMES Athur HAMILTON
-
依托单位:
FATTY ACID TRANSPORT--STRUCTURAL AND CELL BIOLOGY
-
批准号:6241707
-
项目类别:
-
资助金额:$32.32万
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财政年份:1997
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负责人:JAMES Athur HAMILTON
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依托单位:
NMR STUDIES OF LIPIDS IN DISEASES
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批准号:6125772
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项目类别:
-
资助金额:$18.15万
-
财政年份:1991
-
负责人:JAMES Athur HAMILTON
-
依托单位:
NMR STUDIES OF LIPIDS IN DISEASES
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批准号:2502668
-
项目类别:
-
资助金额:$19.62万
-
财政年份:1991
-
负责人:JAMES Athur HAMILTON
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依托单位:
NMR STUDIES OF WEAKLY POLAR LIPIDS
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批准号:2220194
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项目类别:
-
资助金额:$17.78万
-
财政年份:1991
-
负责人:JAMES Athur HAMILTON
-
依托单位:
NMR STUDIES OF WEAKLY POLAR LIPIDS
-
批准号:2220193
-
项目类别:
-
资助金额:$16.82万
-
财政年份:1991
-
负责人:JAMES Athur HAMILTON
-
依托单位:
海外基金