CHILDRENS CANCER GROUP--COMPETITIVE GRANT RENEWAL

玛格丽特公主儿童医院(PMH)是西澳大利亚州唯一的三级大学附属儿科教学医院，也是该州唯一提供多学科儿科肿瘤学服务的医院，该州有200万人口。玛嘉烈医院是北美以外唯一一家被接受为CCG成员的医院(1990年11月当选)。1992年11月实现了从预备会员到正式会员的晋升。在过去的12个月里，PMH已经让70名患者接受了CCG治疗、生物和非治疗研究。根据标准化的CCG排名系统，玛嘉烈医院在1997年的整体机构排名中达到19位(1996年为26位)，是CCG附属医院中改善幅度最大的。肿瘤科设在一个专门建造的“全面护理单元”内，其中包括在一个地方管理癌症儿童及其家人所需的所有服务和学科，包括住院、造血干细胞移植、同日护理、门诊、治疗室、药房、数据管理、社会工作、学校教室和护士联络设施。肿瘤科的目标有四个方面：(1)提供最先进的多学科管理，以最大限度地提高治愈儿童肿瘤疾病的可能性。(2)量身定制治疗，将急性毒性和长期有害后遗症降至最低。(3)通过应用IRB批准的合作组临床试验，支持科学合理的临床研究。(4)积极支持CCG批准的生物学研究，促进转译研究。PMH承诺履行所有必要的要求和责任，以保持儿童癌症小组的正式成员资格，这是实现这些目标的最佳方式。玛嘉烈医院肿瘤科的长期目标是在CCG活动中发挥更积极的作用，包括指导和研究委员会以及战略小组成员。

Princess Margaret Hospital for Children (PMH) is the sole tertiary university affiliated paediatric teaching hospital for the State of Western Australia and provides the only multidisciplinary paediatric oncology service in the state, which has a population of 2 million. PMH is the only hospital outside North America honoured by being accepted as a CCG member (elected November 1990). Promotion from probationary to full membership was achieved in November 1992. In the last 12 months PMH has entered 70 patients on CCG therapeutic, biologic and non- therapeutic studies. With respect to the overall institutional ranking for 1997 based on a standardised CCG ranking system, PMH achieved a ranking of 19 (compared with 26 in 1996), the best incremental improvement of all CCG affiliated hospitals. The Oncology Division is housed in a purpose built "Total Care Unit" containing all services and disciplines in the one locality needed to manage children with cancer their families and includes inpatient, haemopoietic stem cell transplant, same day care, outpatient, treatment rooms, pharmacy, data management, social work, school room and nurse liaison facilities. The Oncology Division goals are four-fold: (1) Provide state of the art multidisciplinary management which will maximise probabilities of cure for oncological diseases in children. (2) Tailor curative therapy to minimise both acute toxicity and long term deleterious sequelae. (3) Support scientifically sound clinical research through the application of IRB approved co- operative group clinical trials. (4) Promote translational research through active support of CCG approved biologic studies. These aims are best achieved by PMH's commitment to fulfilling all the requirements and responsibilities necessary in maintaining full membership with the Children's Cancer Group. The long term objective of the Oncology Division at PMH is to play a more pro-active role in CCG activities including steering and study committees and strategy group membership.