NEUROBIOLOGIC SUBSTRATES OF STUTTERING

描述：候选人提出了五年的支持期，以允许 h发展她的研究技能，使她可能成为一个独立的 研究科学家能够利用复杂的技术来执行 MRI数据的定量分析。 在这份提案中，她将使用这些 研究口吃的神经生物学基础的技术，但她 表明测试技术可能最终用于解决各种 临床人群的脑行为关系。 的具体方面 值得注意的建议包括： 研究的主要焦点是试图定义解剖学 基本认知和其他脑功能的定量方法， M图像分析 她在同行评审期刊上发表了8篇论文， 目前正在印刷的手稿和4个正在审查的手稿。 她是第一个 作者6 o出版/出版手稿。 研究计划（根据PI的具体目标修改）：主要目标 这个项目是研究口吃的神经解剖学模型。 实现这些 PI提出的目标是进行四项实验，调查 口吃者和非口吃者之间的关系行为不对称。 实验1将研究言语产生与 前外侧裂周围言语-语言区（pars 三角肌盖部）。 实验2将研究 言语知觉不对称性与后额叶的关系 言语-语言区域（颞平面）。 实验3将研究 运动灵活性与皮质和 皮质下运动区（中央髓、苍白球）。 实验 1，2，3将仅限于一贯的右撇子。 作为手偏好 可能是一个重要的自变量，左撇子口吃者和左撇子 在实验4中，使用相同的 在实验1、2和3中采用的措施。 这个项目将集中在口吃者的大脑优势。 主要 这项研究的假设是，口吃的人有解剖学上的， 支配的行为异常

DESCRIPTION: The candidate proposes a five year period of support to permit h to develop her research skills so that she may become an independent research scientist capable of utilizing sophisticated techniques to perform quantitativ analyses of MRI data. In this proposal she will employ these techniques to investigate the neurobiologic substrate of stuttering, but she suggests that t techniques may ultimately be used to address a variety of brain-behavior relations in clinical populations. Specific aspects of the proposal which warrant attention include the following: The major focus of research has been the attempt to define the anatomic basis cognitive and other brain functions by means of the quantitative analysis of M images. She lists 8 publications in peer-reviewed journals, 3 manuscripts currently In Press and 4 manuscripts under review. She is first author of 6 o the published/in press manuscripts. Research Program (modified from the PI's Specific Aims): The major goal of th project is to study neuroanatomic models of stuttering. To achieve these goal the PI proposes to conduct four experiments that investigate the relationship behavioral asymmetries in people who stutter and nonstutterers. Experiment 1 will investigate the relationship of speech production to asymmetries in anterior perisylvian speech-language regions (pars triangularis pars opercularis). Experiment 2 will investigate the relationship between speech perception asymmetries in posterior speech-language regions (planum temporale). Experiment 3 will investigate the relationship between motor dexterity and asymmetries in cortical and subcortical motor regions (central suclus, globus plallidus). Experiments 1, 2, and 3 will be limited to consistent right handers. As hand preference may be an important independent variable, left handed stutterers and left handed nonstutterers will be investigated in Experiment 4 using the same measures to be employed in Experiments 1, 2, and 3. This project will focus on cerebral dominance in stutterers. The major postulate of the study is that people who stutter have anatomic and behavioral anomalies of dominance.