STRUCTURES AND FUNCTIONS OF CYS3HIS ZINC DOMAINS
STRUCTURES AND FUNCTIONS OF CYS3HIS ZINC DOMAINS
批准号:
6138620
负责人:
Jeremy M. Berg
金额:
$19.43万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-01-01 至 2001-12-31
中文摘要
描述:(改编自申请者的摘要)各种类别的
参与基因表达调控的蛋白质已被发现
包含形成小结构域的短伸展氨基酸
围绕结合的锌离子组织。这些蛋白质中的许多通过
与核酸的相互作用。当前感兴趣的两个类
是CCHC-box结构域蛋白和CCCH结构域蛋白。CCHC-BOX
结构域首次被鉴定为逆转录病毒蛋白质的一种成分
其中,这个领域似乎在单项识别中起着关键作用
搁浅的DNA。已经建立了这些相互作用的结构模型。
这将通过研究与之结合的蛋白质片段来测试
锥虫体内特异的单链DNA序列。CCCH域
在Nup475蛋白中被识别,其水平随着
胰岛素和其他生长因子。CCCH域的功能不是
已经确定了,但最近的结果表明,它们可能会切割特定的
RNA结构。这项提议反映了一种合作努力,以
用溶液状态核磁共振结构表征这两个结构基序
以及功能性和约束性研究。
英文摘要
DESCRIPTION: (adapted from applicant's abstract) A variety of classes of
proteins involved in the regulation of gene expression have been found to
contain short stretches of amino acids that form small structural domains
organized around bound zinc ions. Many of these proteins function via
interactions with nucleic acids. Two classes that are of current interest
are the CCHC-box domain proteins and the CCCH domain proteins. The CCHC-box
domain was first identified as a component of proteins from retroviruses
where this domain appears to play a key role in the recognition of single
stranded DNA. A structural model of these interactions has been developed
that will be tested via studies of fragments of a protein that binds to
specific single stranded DNA sequences from trypanosomes. The CCCH domain
was recognized in the protein Nup475 whose level increases in response to
insulin and other growth factors. The functions of CCCH domains are not
well established, but recent results suggest that they may cleave specific
RNA structures. This proposal reflects a collaborative effort to
characterize these two structural motifs using solution state NMR structures
as well as functional and binding studies.
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会议论文
CORE--CORE FACILITY
-
批准号:6338831
-
项目类别:
-
资助金额:$12.73万
-
财政年份:2000
-
负责人:Jeremy M. Berg
-
依托单位:
CORE--CORE FACILITY
-
批准号:6316672
-
项目类别:
-
资助金额:$18.31万
-
财政年份:2000
-
负责人:Jeremy M. Berg
-
依托单位:
COUPLED METAL BINDING-PROTEIN FOLDING REACTIONS
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批准号:6338826
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项目类别:
-
资助金额:$12.73万
-
财政年份:2000
-
负责人:Jeremy M. Berg
-
依托单位:
COUPLED METAL BINDING-PROTEIN FOLDING REACTIONS
-
批准号:6316667
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项目类别:
-
资助金额:$18.31万
-
财政年份:2000
-
负责人:Jeremy M. Berg
-
依托单位:
COUPLED METAL BINDING-PROTEIN FOLDING REACTIONS
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批准号:6107701
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项目类别:
-
资助金额:$18.31万
-
财政年份:1999
-
负责人:Jeremy M. Berg
-
依托单位:
CORE--CORE FACILITY
-
批准号:6107706
-
项目类别:
-
资助金额:$18.31万
-
财政年份:1999
-
负责人:Jeremy M. Berg
-
依托单位:
CORE--CORE FACILITY
-
批准号:6271820
-
项目类别:
-
资助金额:$17.7万
-
财政年份:1998
-
负责人:Jeremy M. Berg
-
依托单位:
STRUCTURES AND FUNCTIONS OF CYS3HIS ZINC DOMAINS
-
批准号:2857343
-
项目类别:
-
资助金额:$19.03万
-
财政年份:1998
-
负责人:Jeremy M. Berg
-
依托单位:
STRUCTURES AND FUNCTIONS OF CYS3HIS ZINC DOMAINS
-
批准号:6342985
-
项目类别:
-
资助金额:$19.85万
-
财政年份:1998
-
负责人:Jeremy M. Berg
-
依托单位:
STRUCTURES AND FUNCTIONS OF CYS3HIS ZINC DOMAINS
-
批准号:2464849
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项目类别:
-
资助金额:$21.66万
-
财政年份:1998
-
负责人:Jeremy M. Berg
-
依托单位:
COUPLED METAL BINDING-PROTEIN FOLDING REACTIONS
-
批准号:6271815
-
项目类别:
-
资助金额:$17.7万
-
财政年份:1998
-
负责人:Jeremy M. Berg
-
依托单位:
CORE--CORE FACILITY
-
批准号:6240602
-
项目类别:
-
资助金额:$17.12万
-
财政年份:1997
-
负责人:Jeremy M. Berg
-
依托单位:
COUPLED METAL BINDING-PROTEIN FOLDING REACTIONS
-
批准号:6240597
-
项目类别:
-
资助金额:$17.12万
-
财政年份:1997
-
负责人:Jeremy M. Berg
-
依托单位:
STRUCTURAL/THERMODYMANIC STUDIES OF FOLDING AND BINDING
-
批准号:6017077
-
项目类别:
-
资助金额:$109.86万
-
财政年份:1996
-
负责人:Jeremy M. Berg
-
依托单位:
STRUCTURAL/THERMODYMANIC STUDIES OF FOLDING AND BINDING
-
批准号:2713730
-
项目类别:
-
资助金额:$106.21万
-
财政年份:1996
-
负责人:Jeremy M. Berg
-
依托单位:
STRUCTURAL/THERMODYMANIC STUDIES OF FOLDING AND BINDING
-
批准号:6335718
-
项目类别:
-
资助金额:$3.78万
-
财政年份:1996
-
负责人:Jeremy M. Berg
-
依托单位:
STRUCTURAL/THERMODYMANIC STUDIES OF FOLDING AND BINDING
-
批准号:2430478
-
项目类别:
-
资助金额:$102.71万
-
财政年份:1996
-
负责人:Jeremy M. Berg
-
依托单位:
STRUCTURAL/THERMODYMANIC STUDIES OF FOLDING AND BINDING
-
批准号:2189838
-
项目类别:
-
资助金额:$105.19万
-
财政年份:1996
-
负责人:Jeremy M. Berg
-
依托单位:
STRUCTURAL/THERMODYMANIC STUDIES OF FOLDING AND BINDING
-
批准号:6180420
-
项目类别:
-
资助金额:$113.82万
-
财政年份:1996
-
负责人:Jeremy M. Berg
-
依托单位:
MIRROR IMAGE PROTEINS
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批准号:2186734
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项目类别:
-
资助金额:$10.0万
-
财政年份:1993
-
负责人:Jeremy M. Berg
-
依托单位:
国内基金
海外基金
基于cysteine代谢在内皮损伤中的作用探讨其在SARSCoV-2感染的致病机理及可能的治疗机制
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项目类别:国际(地区)合作与交流项目
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批准年份:2020
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负责人:汪道文
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依托单位: