A macrophage transmembrane adaptor: scaffolding and regulation in inflammation.

点击翻译按钮获取中文摘要

Uncontrolled inflammation underlies chronic inflammatory and autoimmune diseases, like lupus. Macrophages are cells that control inflammation through their networks of molecular receptors, adaptors, signals and cytokine messengers. Our project will define new regulatory proteins and pathways within this network that control inflammation and are also associated with lupus. The outcomes will generate essential knowledge and expand therapeutic options for control of inflammation in disease.