A macrophage transmembrane adaptor: scaffolding and regulation in inflammation.

失控的炎症是慢性炎症和自身免疫性疾病的基础，如狼疮。巨噬细胞是通过其分子受体、适配器、信号和细胞因子信使网络控制炎症的细胞。我们的项目将定义这个网络中控制炎症和与狼疮相关的新的调节蛋白和途径。这些成果将产生基本的知识，并扩大控制疾病炎症的治疗选择。

Uncontrolled inflammation underlies chronic inflammatory and autoimmune diseases, like lupus. Macrophages are cells that control inflammation through their networks of molecular receptors, adaptors, signals and cytokine messengers. Our project will define new regulatory proteins and pathways within this network that control inflammation and are also associated with lupus. The outcomes will generate essential knowledge and expand therapeutic options for control of inflammation in disease.