NEUROENDOCRINE PEPTIDES AND THEIR RECEPTORS REGULATING CORTICOTROPHES

神经内分泌肽及其调节皮质激素的受体

• 批准号: 6105161
• 负责人: WYLIE W. VALE
• 金额: $ 21.48万
• 依托单位: SALK INSTITUTE FOR BIOLOGICAL STUDIES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6105161
• 关键词: corticotropin releasing factor; endocrine pharmacology; gene expression; genetic regulatory element; genetically modified animals; glucocorticoids; hormone binding protein; hormone receptor; hormone regulation /control mechanism; immunocytochemistry; in situ hybridization; laboratory mouse; laboratory rabbit; laboratory rat; molecular cloning; neuroendocrine system; neuropeptides; neuroregulation; nucleic acid sequence; pituitary gland; protein kinase A; protein kinase C; protein structure function; receptor expression; transcription factor; vasopressins

Corticotropin releasing factor (CRF) is the key neuroregulatory of the releasing factor (CRF) is the key neuroregulator of the mediate many endocrine, neuroendocrine, autonomic and behavioral responses mediate many endocrine neuroendocrine autonomic and behavioral responses the peptide and its binding sites when considered with many biological the peptide and its binding sites when considered with many biological the central nervous, immune and other systems. The actions of CRF are within the central nervous immune and other systems. The actions of CRF of which was cloned by this project during the last grant period and shown first of which was cloned by this project during the last grant period distributed in pituitary corticotropes and throughout the CNS. We will cyclase and to be distributed in pituitary corticotropes and throughout receptor by CRF and other corticotrope regulators such as glucocorticoids receptor by CRF and other corticotrope regulators such as glucocorticoids mechanisms of ligand-mediated down regulation and desensitization will be mechanisms of ligand-mediated down regulation and desensitization will binding and signal generation and for regulation of receptor sensitivity binding and signal generation and for regulation of receptor sensitivity Project II, the ligand structural requirements for binding to the cloned Project II the ligand structural requirements for binding to the cloned protein, also cloned and studied by us during the past period. An protein also cloned and studied by us during the past period. An we will screen for cDNA's encoding this gene and will complete its analysis we will screen for cDNA s encoding this gene and will complete its will be identified by molecular biological techniques or will be purified related ligands will be identified by molecular biological techniques or will be purified and chemically characterized

促肾上腺皮质激素释放因子(CRF)是促肾上腺皮质激素释放的关键神经调节因子。 释放因子(CRF)是血管紧张素转换酶的关键神经调节因子。 调节多种内分泌、神经内分泌、自主神经和行为反应 调节多种内分泌、神经内分泌、自主神经和行为反应 当与多种生物结合时，该多肽及其结合部位 当与多种生物结合时，该多肽及其结合部位 中枢神经、免疫等系统。CRF的行动是 在中枢神经免疫和其他系统内。慢性肾功能衰竭的作用 它是由该项目在上一次拨款期间克隆的，并显示了 其中第一个是这个项目在上一次拨款期间克隆的 分布于垂体促肾上腺皮质激素和整个中枢神经系统。我们会 环化酶，分布于脑下垂体促肾上腺皮质激素和全身 CRF和其他皮质激素调节剂(如糖皮质激素)的受体 CRF和其他皮质激素调节剂(如糖皮质激素)的受体 配体介导的下调和脱敏的机制将是 配体介导的下调和脱敏机制将 结合和信号产生以及受体敏感性的调节 结合和信号产生以及受体敏感性的调节 项目II，与克隆的配体结合的结构要求 项目二：与克隆的配体结合的结构要求 蛋白质，也是我们在过去的一段时间里克隆和研究的。一个 蛋白质也是我们在过去的一段时间里克隆和研究的。一个 我们将筛选编码该基因的cDNAs，并完成其分析 我们将筛选编码该基因的cDNAS并完成其 将通过分子生物学技术鉴定或将被提纯 相关的配体将通过分子生物学技术或 将被提纯并进行化学表征