CORE--TRANSPORTER DATABASE AND STRUCTURE WEBSITE

核心--转运数据库及网站结构

• 批准号: 6197158
• 负责人: GARY W RUDNICK
• 金额: --
• 依托单位: MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-09 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6197158
• 关键词: Internet; biomedical facility; chemical information system; membrane transport proteins; protein structure function

Many laboratories are making mutations in the serotonin, norepinephrine, and dopamine transporters (SERT, NET and DAT, respectively) and in related transporters in the NaCl-coupled transporter family. The properties of these transporter mutants are published in many scientific articles scattered widely through the literature. This core will create a database of all published mutations in any member of this transporter family. The mutations will be organized according to position, family member and the effect on transporter function. The results will be presented in a World Wide Web site so that anyone can access the information easily. We expect that this will facilitate the rapid sharing of information in this field, and will benefit many drug abuse researchers. As the structural modeling efforts become more refined by the experimental results from this program, we intend also to display the current structural model for the transporter family. A three dimensional representation of this model will be available for visitors to the website to tilt and rotate using VRML (Virtual Reality Markup Language).

许多实验室正在对5-羟色胺、去甲肾上腺素和多巴胺转运体(分别为SERT、Net和DAT)以及氯化钠偶联转运体家族的相关转运体进行突变。这些转运蛋白突变体的特性发表在许多科学文章中，分散在广泛的文献中。这个核心将创建一个数据库，其中包含这个转运蛋白家族中任何成员的所有已公布的突变。突变将根据位置、家庭成员和对转运蛋白功能的影响进行组织。结果将在万维网上公布，这样任何人都可以轻松地访问这些信息。我们预计，这将促进这一领域的信息快速共享，并将使许多药物滥用研究人员受益。随着本程序的实验结果使结构建模工作变得更加精细，我们还打算显示传送器族的当前结构模型。该模型的三维表示将可供网站访问者使用VRML(虚拟现实标记语言)进行倾斜和旋转。