CORE--TRANSPORTER DATABASE AND STRUCTURE WEBSITE

许多实验室正在制造5 -羟色胺、去甲肾上腺素和多巴胺转运蛋白（分别为SERT、NET和DAT）以及nacl偶联转运蛋白家族中相关转运蛋白的突变。这些转运体突变体的特性被广泛地发表在许多科学文章中。该核心将创建一个包含该转运蛋白家族任何成员的所有已发表突变的数据库。突变将根据位置、家族成员和对转运蛋白功能的影响来组织。调查结果将在一个万维网网站上公布，以便任何人都能方便地获取这些信息。我们期望这将促进这一领域信息的快速共享，并将使许多药物滥用研究人员受益。由于这个项目的实验结果使结构建模工作变得更加完善，我们也打算展示目前转运体家族的结构模型。该模型的三维表示将提供给网站访问者使用VRML（虚拟现实标记语言）进行倾斜和旋转。

Many laboratories are making mutations in the serotonin, norepinephrine, and dopamine transporters (SERT, NET and DAT, respectively) and in related transporters in the NaCl-coupled transporter family. The properties of these transporter mutants are published in many scientific articles scattered widely through the literature. This core will create a database of all published mutations in any member of this transporter family. The mutations will be organized according to position, family member and the effect on transporter function. The results will be presented in a World Wide Web site so that anyone can access the information easily. We expect that this will facilitate the rapid sharing of information in this field, and will benefit many drug abuse researchers. As the structural modeling efforts become more refined by the experimental results from this program, we intend also to display the current structural model for the transporter family. A three dimensional representation of this model will be available for visitors to the website to tilt and rotate using VRML (Virtual Reality Markup Language).