ALTERATIONS IN SKELETAL MUSCLE STRUCTURE AND FUNCTION IN HIV INFECTION

以前的研究记录了严重的， 艾滋病患者的进行性营养不良。我们的长期目标是 研究的目的是为了了解糖尿病的发病机制。 艾滋病患者营养不良--营养支持的科学依据 治疗，以及对这种治疗结果的现实期望 心理治疗。这项建议的具体目的是界定 身体变化背后的代谢机制 由于获得性免疫而产生的成分 虚证，其与活动性艾滋病毒感染的关联， 以及它们与细胞因子释放变化的关系。这个 这些研究的中心将是对身体的精确测量 将允许精确测定消耗的成分 或者是回收。将采取两种方法来研究这个问题。 将对一组无症状、HIV血清阳性的男性进行研究 并在纵向上跟随。据估计，一个子群 将经历临床进展，而这些变化将 包括身体质量消耗。关于能源利用和环境保护的研究 将执行衬底助熔剂以确定哪种类型的 在疾病的哪个时间点会发生变化。相关性 将与血清细胞因子水平进行比较。另一种方法 将对营养不良的艾滋病患者进行研究 营养或抗病毒治疗。最近的研究表明 论证了为以下人群提供营养支持的可行性 这些患者表现出身体质量因以下原因而减少 有效的抗病毒治疗。营养学研究将是 在补给期间进行的测试和结果 与血清细胞因子水平相关。在后来的几年里， 调节细胞因子释放的营养代谢效应 将会被研究。缓解营养不良的能力 艾滋病慢性感染的后果可能在 减少此类并发症的发病率。

Previous studies documented the frequent occurrence of severe, progressive malnutrition in AIDS. The long-term goal of our studies is to provide an understanding of the pathogenesis of malnutrition in AIDS, a scientific rationale for nutritional therapy, and realistic expectations for the results of such therapy. The specific aims of this proposal are to define the metabolic mechanisms underlying the alterations in body composition that occur as a result of the acquired immune deficiency syndrome, their association with active HIV infection, and their relationship to altered release of cytokines. The centerpiece of these studies will be precise measurements of body composition which will allow precise determination of depletion or repletion. Two approaches will be taken to study the problem. A cohort of asymptomatic, HIV-seropositive men will be studied and followed longitudinally. Estimations are that a subgroup will undergo clinical progression, and that the changes will include body mass depletion. Studies of energy utilization and substrate flux will be performed to determine what type of alterations occur and at what point in the disease. Correlations will be made with serum levels of cytokines. The other approach will be to study malnourished AIDS patients who are undergoing nutritional or antiviral therapy. Recent studies have demonstrated the feasibility of providing nutritional support to these patients and have shown body mass repletion as a result of effective antiviral therapy. Nutritional studies will be performed during the period of repletion and the results correlated with serum levels of cytokines. In later years, the nutritional and metabolic effects of modulating cytokine release will be studied. The ability to mitigate the nutritional consequences of chronic infections in AIDS may be important in reducing the morbidity of such complications.