课题基金 / 基金详情

PREF-1 FUNCTION IN ISLET GROWTH & DIFFERENTIATION

PREF-1 FUNCTION IN ISLET GROWTH & DIFFERENTIATION
PREF-1 在胰岛生长中的作用
批准号：
6053996
负责人：
Hei Sook Sul
金额：
$14.8万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-09-30 至 2001-08-31
来源：
https://reporter.nih.gov/project-details/6053996
关键词：
adipocytes cell differentiation cell growth regulation cell proliferation developmental genetics epidermal growth factor gene expression genetically modified animals laboratory mouse mammalian embryology membrane proteins pancreatic islets protein structure function transcription factor

项目摘要

项目成果

Hei Sook Sul的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
DESCRIPTION: (Adapted from the applicant's abstract) Preadipocyte factor 1 (pref- 1) is a transmembrane protein that contains epidermal growth factor-like repeats. Pref- 1 can be cleaved to generate a soluble factor. Using differential screening ,the investigators originally cloned pref-l from embryonally- derived 3T3-Ll cells. The correlative observations suggest a role for pref- 1 during growth and differentiation of islet 3-cells. The specific aims of this exploratory grant proposal are: 1) To demonstrate pref- I function in 13-cell growth and differentiation by generating transgenic mice overexpressing pref- 1 driven by the insulin promoter. 2) To examine the effect of pref- 1 during in differentiation and growth of AR42J cells into insulin-positive endocrine cells.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
MICT1 function in thermogenesis
Brown adipose NADH oxidase for thermogenesis
Brown adipose NADH oxidase for thermogenesis
Brown adipose NADH oxidase for thermogenesis
海外基金