CONTROLLED TRANSFER MODEL FOR AUTOIMMUNE DIABETES

自身免疫性糖尿病的受控转移模型

• 批准号: 6116402
• 负责人: WILLIAM HAGOPIAN
• 金额: $ 8.67万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116402
• 关键词: Mammalia; Primates; diabetes mellitus; immunology; inflammation; model design /development

The research plan consists of the following: 1) Identification and molecular cloning of novel beta-cell antigens obtained from the macaque, subsequent determination of tissue distribution and measurement of the human immune response to these antigens; 2) Characterization of the islet factors that influence beta-cell autoantigen expession levels in Type 1 Diabetes; 3) Development of a non-human primate model of beta-cell transfection for antigen overexpression and beta-cell immortalization.

研究计划包括：1)从猕猴中获得新的β细胞抗原的鉴定和分子克隆，随后确定组织分布和测量人类对这些抗原的免疫反应；2)表征影响1型糖尿病患者β细胞自身抗原表达水平的胰岛因素；3)建立非人类灵长类β细胞转染模型，用于抗原过度表达和β细胞永生化。