INFLUENCE OF OBESITY ON ENDOGENOUS SUBSTRATE UTILIZATION DURING EXERCISE

肥胖对运动期间内源性底物利用的影响

• 批准号: 6264150
• 负责人: Bret H Goodpaster
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264150
• 关键词: body composition; calorimetry; carbohydrate metabolism; clinical research; clinical trial phase I; exercise; free fatty acids; glucose; human subject; lipid metabolism; male; obesity; radiotracer

The primary objective of this study will be to examine the hypothesis that lipid oxidation during low intensity exercise is reduced in obese versus lean individuals. This study will measure lipid and carbohydrate utilization during exercise and test the hypothesis that lipid oxidation during exercise is impaired in obesity. Lean and obese sedentary males will be recruited for this study. Defects in the regulation of skeletal muscle metabolism are present at rest in obese individuals, although information regarding substrate utilization during exercise in obesity is scarce. Body composition will be determined by DEXA. Substrate utilization during 60 minutes of exercise will be determined using indirect calorimetry and stable isotope tracers of free fatty acids (FFA) and glucose.

这项研究的主要目的是检查以下假设：在肥胖个体与瘦的个体中，低强度运动过程中的脂质氧化降低。 这项研究将在运动过程中测量脂质和碳水化合物的利用，并检验肥胖症中脂质氧化的假设。 这项研究将招募精益和肥胖的久坐男性。 肥胖个体中静止存在骨骼肌代谢的缺陷，尽管有关肥胖运动过程中底物利用的信息很少。 身体成分将由DEXA确定。 在运动的60分钟内使用底物利用率将使用自由脂肪酸（FFA）和葡萄糖的间接量热法和稳定的同位素示踪剂确定。