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INFLUENCE OF OBESITY ON ENDOGENOUS SUBSTRATE UTILIZATION DURING EXERCISE

INFLUENCE OF OBESITY ON ENDOGENOUS SUBSTRATE UTILIZATION DURING EXERCISE
肥胖对运动期间内源性底物利用的影响
批准号：
6264150
负责人：
Bret H Goodpaster
金额：
$0.3万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6264150
关键词：
body composition calorimetry carbohydrate metabolism clinical research clinical trial phase I exercise free fatty acids glucose human subject lipid metabolism male obesity radiotracer

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英文摘要
The primary objective of this study will be to examine the hypothesis that lipid oxidation during low intensity exercise is reduced in obese versus lean individuals. This study will measure lipid and carbohydrate utilization during exercise and test the hypothesis that lipid oxidation during exercise is impaired in obesity. Lean and obese sedentary males will be recruited for this study. Defects in the regulation of skeletal muscle metabolism are present at rest in obese individuals, although information regarding substrate utilization during exercise in obesity is scarce. Body composition will be determined by DEXA. Substrate utilization during 60 minutes of exercise will be determined using indirect calorimetry and stable isotope tracers of free fatty acids (FFA) and glucose.
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