INFLUENCE OF OBESITY ON ENDOGENOUS SUBSTRATE UTILIZATION DURING EXERCISE

肥胖对运动期间内源性底物利用的影响

• 批准号: 6264150
• 负责人: Bret H Goodpaster
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264150
• 关键词: body composition; calorimetry; carbohydrate metabolism; clinical research; clinical trial phase I; exercise; free fatty acids; glucose; human subject; lipid metabolism; male; obesity; radiotracer

The primary objective of this study will be to examine the hypothesis that lipid oxidation during low intensity exercise is reduced in obese versus lean individuals. This study will measure lipid and carbohydrate utilization during exercise and test the hypothesis that lipid oxidation during exercise is impaired in obesity. Lean and obese sedentary males will be recruited for this study. Defects in the regulation of skeletal muscle metabolism are present at rest in obese individuals, although information regarding substrate utilization during exercise in obesity is scarce. Body composition will be determined by DEXA. Substrate utilization during 60 minutes of exercise will be determined using indirect calorimetry and stable isotope tracers of free fatty acids (FFA) and glucose.

本研究的主要目的将是检验这一假设，即在低强度运动过程中，肥胖与瘦个体的脂质氧化减少。 本研究将测量运动过程中的脂质和碳水化合物利用率，并检验肥胖者运动过程中脂质氧化受损的假设。 本研究将招募消瘦和肥胖久坐男性。 虽然关于肥胖症患者运动过程中底物利用的信息很少，但肥胖患者在休息时存在骨骼肌代谢调节的缺陷。 身体成分将由DEXA测定。 将使用间接量热法和游离脂肪酸（FFA）和葡萄糖的稳定同位素示踪剂测定60分钟运动期间的底物利用率。