EFFECT OF HAIR GROWTH BY PROSTAGLANDIN F2A ANALOGUE

目的观察拉坦前列素(50和500 ug/ml)的药效。 短尾猴秃顶头皮毛发再生的解决方案 结果兰塔诺前列素(沙拉坦)治疗青光眼疗效显著 睫毛上特殊的多毛症副作用；毛发变长 而且更厚。我们研究了拉坦前列素对头发再生的影响。 在秃头猕猴身上。拉坦前列素，50微克/毫升和500微克/毫升，每次0.5毫升 日，局部涂抹在四只猴子的秃顶头皮上，持续3至3天 8个月。另外四只猴子被单独给予车辆5到8次 月份。评估是通过1)月度全球照片，2) 头皮活检皮肤毛囊生长的显微形态计量学研究 (毛囊图分析)，以及3)转化率的毛发计数 从鹿茸毛发到中间型或终端型 头发和毛囊再生的影响是 呈剂量依赖性。拉坦前列素(500ug/ml)引起显著升高 毛发的长度和密度增加80%以上，毛囊 生长，顶毛增加27%至74% 0时间和3个月的US数据。沙拉坦(拉坦前列素，50ug/ml)显示 即使经过较长时间的治疗，毛发和毛囊的生长程度也很低 期间(8个月)。拉坦前列素，浓度相对较低 (0.05%)，可显著促进恒河猴秃顶的卵泡再生。 头皮。检测这种药物的系统性副作用的未来方向 强效毛发生长刺激剂的临床应用 治疗脱发关键词拉坦前列素。毛发生长。秃顶。 短尾猴资助Pharmacia Upjohn公司

OBJECTIVE To examine the effect of latanoprost (50 and 500 ug/ml) solutions on hair regrowth in the bald scalp of stumptailed macaques RESULTS Lantanoprost (Xalatan) using treatment for glaucoma has a peculiar hypertrichotic side effect on eyelashes; hairs grow longer and thicker. We examined the effect of latanoprost on hair regrowth in the bald macaque. Latanoprost, 50ug/ml and 500ug/ml, 0.5 ml per day, were topically applied on the bald scalp of four monkeys for 3 to 8 months. Another four monkeys were given vehicle alone for 5 to 8 months. Evaluations were made by 1) monthly global photographs, 2) micromorphometry of follicular growth in biopsied scalp skin (folliculogram analysis), and 3) hair counts for the conversion rates of vellus hair to intermediary or to terminal types (phototrichography).The effects of hair and follicular regrowth were dose-dependent. Latanoprost (500ug/ml) induced significant increase of length and density of hairs, over 80% increase of follicular growth, and 27 to 74% increase of terminal hairs, in those compared to 0 time and 3 monthUs data. Xalatan (latanoprost, 50ug/ml) showed minimal degree of hair and follicular growth even by longer treatment period (8 months). Latanoprost, with its relatively low concentration (0.05%), markedly stimulated follicular regrowth in the macaque bald scalp. FUTURE DIRECTIONS To detect systemic side effects of this potent hair growth stimulator for clinical application of the treatment of baldness KEY WORDS latanoprost. Hair growth. Baldness. Stumptailed macaque FUNDING Pharmacia Upjohn Company