COMPARE LOW DOSE TO TRADITIONAL ACTH TESTS DURING GLUCOCORTICOID WITHDRAWAL

该方案比较了两种肾上腺反应性测试( 传统大剂量ACTH试验与新的小剂量ACTH试验的比较 在最近接受过外源性糖皮质激素治疗的患者。在这些 患者，大剂量测试将按月进行，直到 它会正常化。之后，将进行低剂量测试，直到 正常化。将考虑到第二个事件之前的时间间隔 随着下丘脑-垂体-肾上腺轴的完全恢复， 并应确认这一新的评估工具具有更高的敏感性 患者需要多长时间才能注意肾上腺的可能性 停用类固醇后的功能不全。

This protocol compares two tests of adrenal responsiveness (the traditional high dose ACTH test vs the new low dose ACTH test) in patients who have received exogenous glucocorticoids in the recent past. In these patients, the high dose test will be performed on a monthly basis, until it normalizes. After that, the low dose test will be performed until it normalizes. The time interval until this second event will be considered as the complete recovery of the hypothalamic - pituitary - adrenal axis, and should confirm the higher sensitivity of this new tool for assessing how long patents have to be careful about the possibility of adrenal insufficiency after steroid withdrawl.