INSULIN RESPONSE TO PROLONGED HYPERGLYCEMIA IN FIRST DEGREE RELATIVES

一级亲属胰岛素对长期高血糖的反应

• 批准号: 6116999
• 负责人: Guenther Boden
• 金额: $ 5.92万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116999
• 关键词: clinical research; family genetics; glucose tolerance; hormone regulation /control mechanism; human subject; hyperglycinemia; insulin; noninsulin dependent diabetes mellitus; pancreatic islets

The specific aim of this project is to investigate whether beta cell adaptation to prolonged hyperglycemia is defective in glucose tolerant first degree relatives with non-insulin dependent diabetes mellitus (NIDDM) as compared with normal subject.

本研究的具体目的是探讨非胰岛素依赖型糖尿病(NIDDM)患者的一级糖耐量亲属(NIDDM)的胰岛β细胞对长期高血糖的适应性是否存在缺陷。