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GENE MAPPING IN WOMEN W/ SYSTEMIC LUPUS

GENE MAPPING IN WOMEN W/ SYSTEMIC LUPUS
患有系统性狼疮的女性的基因图谱
批准号：
6264836
负责人：
RONALD P MESSNER
金额：
$4.48万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6264836
关键词：
MHC class II antigen T cell receptor cell line clinical research family genetics female genetic mapping genetic polymorphism genetic susceptibility human subject immunogenetics molecular biology information system patient /disease registry systemic lupus erythematosus tissue /cell culture

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中文摘要
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英文摘要
Systemic lups erthematosus is an autoimmune disease of unknown etiology. There is convincing epidemiological evidence that SLE clusters in families, suggesting a genetic basis for the disease. Our hypothesis, based on a large body of evidence, is that SLE is an oligogenic disease, with the inheritance of a few genes other than MHC and TCR contributing to susceptibility. We propose to use gene mapping with highly informative, short tandem repeat polymorphism's (STRPs) in sibling pairs and multiplex families with SLE. In the course of the study we will establish a detailed database of clinical and family history data, determine Class II genotypes, and establish a repository of sera, DNA and immortalized cell lines for each subject.
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  • 依托单位：
    UNIVERSITY OF MINNESOTA
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  • 依托单位：
    UNIVERSITY OF MINNESOTA
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