GENE MAPPING IN WOMEN W/ SYSTEMIC LUPUS

患有系统性狼疮的女性的基因图谱

• 批准号: 6264836
• 负责人: RONALD P MESSNER
• 金额: $ 4.48万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264836
• 关键词: MHC class II antigen; T cell receptor; cell line; clinical research; family genetics; female; genetic mapping; genetic polymorphism; genetic susceptibility; human subject; immunogenetics; molecular biology information system; patient /disease registry; systemic lupus erythematosus; tissue /cell culture

Systemic lups erthematosus is an autoimmune disease of unknown etiology. There is convincing epidemiological evidence that SLE clusters in families, suggesting a genetic basis for the disease. Our hypothesis, based on a large body of evidence, is that SLE is an oligogenic disease, with the inheritance of a few genes other than MHC and TCR contributing to susceptibility. We propose to use gene mapping with highly informative, short tandem repeat polymorphism's (STRPs) in sibling pairs and multiplex families with SLE. In the course of the study we will establish a detailed database of clinical and family history data, determine Class II genotypes, and establish a repository of sera, DNA and immortalized cell lines for each subject.

系统性红斑肿是一种病因不明的自身免疫性疾病。有令人信服的流行病学证据表明SLE聚集在家族中，表明该疾病有遗传基础。基于大量证据，我们的假设是SLE是一种寡源性疾病，除MHC和TCR外，少数基因的遗传有助于易感性。我们建议使用高信息量的基因定位，短串联重复多态性（STRPs）在兄弟姐妹对和多重SLE家族中。在研究过程中，我们将建立一个详细的临床和家族史数据数据库，确定II类基因型，并为每个受试者建立血清、DNA和永生化细胞系的存储库。