ENDOTHELIAL FUNCTION USING BRACHIAL ARTERY ULTRASOUND

使用肱动脉超声检查内皮功能

• 批准号: 6117242
• 负责人: Joseph A. Vita
• 金额: $ 3.05万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117242
• 关键词: angiocardioultrasonography; cardiovascular disorder diagnosis; clinical research; clinical trials; coronary disorder; diabetes mellitus therapy; diet therapy; disease /disorder proneness /risk; hormone therapy; human subject; human therapy evaluation; nitric oxide; rehabilitation; smoking cessation; vascular endothelium; vasomotion

This study will non-invasively investigate endothelial function in patients with cardiac risk factors and with established coronary artery disease. Patients will undergo testing of endothelial mediated nitric oxide release in the brachial artery using a recently developed, non-invasive ultrasound method. Brachial responses determined by this method were recently shown to closely correlate with nitric oxide dependant vasodilation in the coronary circulation.

这项研究将无创地研究患有心脏危险因素和已确诊冠状动脉疾病的患者的内皮功能。患者将使用最近开发的非侵入性超声方法对肱动脉内皮介导的一氧化氮释放进行测试。 最近表明，通过这种方法确定的肱骨反应与冠状循环中一氧化氮依赖性血管舒张密切相关。