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DIRECT EFFECTS OF PIOGLITAZONE ON GLUCONEOGENESIS IN TYPE II DIABETES

DIRECT EFFECTS OF PIOGLITAZONE ON GLUCONEOGENESIS IN TYPE II DIABETES
吡格列酮对 II 型糖尿病糖异生的直接影响
批准号：
6264894
负责人：
JOHN A TAYEK
金额：
$0.1万
依托单位：
LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6264894
关键词：
clinical research drug screening /evaluation gluconeogenesis glucose metabolism human subject human therapy evaluation hypoglycemic agents leucine noninsulin dependent diabetes mellitus oxidation protein metabolism

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英文摘要
Type II diabetes is associated with a 30 to 70% increase in liver glucose relea-se. This raises fasting blood glucose. This research will study the direct eff-ect of a new diabetic medication on gluconeogenesis and protein catabolism in normals and in type II diabetes. Diabetics are known to have an elevated rate of gluconeogenesis and an elevated rate of leucine oxidation. This new medication is known to reduce glucose release from the liver, but it is not known if it is decreasing gluconeogenesis, glycogen breakdown, or leucine oxidation.
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ABNORMAL GLUCONEOGENESIS IN TYPE II DIABETES