EPIDEMIOLOGY OF CORONARY ARTERY CALCIFICATION

冠状动脉钙化的流行病学

• 批准号: 6117409
• 负责人: P F SHEEDY
• 金额: $ 2.01万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117409
• 关键词: atherosclerosis; calcification; cardiovascular disorder diagnosis; cardiovascular disorder epidemiology; clinical research; coronary artery; coronary disorder; human subject

This study takes advantage of electron beam CT measures of quantity of coronary artery calcification, measured CAD risk factors, and stored buffy coats on over 600 asymptomatic adults, and new data to be collected on 500 of their siblings. Understanding genetic susceptibility to asymptomatic atherosclerosis measured by quantity of CAC will increase our understanding of atherosclerosis and improve early identification of individuals who will benefit most from existing or new interventions.

本研究利用电子束CT测量600多名无症状成年人的冠状动脉钙化量、测量CAD危险因素和储存的灰白色涂层，并收集500名兄弟姐妹的新数据。通过测量CAC的数量来了解无症状动脉粥样硬化的遗传易感性将增加我们对动脉粥样硬化的理解，并改善早期识别那些将从现有或新的干预措施中获益最多的个体。