MOLEC MODEL OF COFILIN REGULATION IN ACTIN FILAMENT DYNAMICS & CELL FUNCTIONS

脊椎动物视网膜的视觉是由光激活的G 位于感光细胞盘膜上的蛋白偶联途径 细胞 通过这一途径的信号传导涉及形成和 多种膜依赖性蛋白复合物的活化。 我们 正在研究这些复合物的结构，因为它们存在于 膜表面的电子晶体学。 我们形成了 异三聚体形式的二维晶体和螺旋阵列 并通过冷冻电子显微镜对其成像。 图像 螺旋结构的处理揭示了 计算傅立叶变换超过18
，并对这些 transforms正在进行中。

Vision in vertebrate retinas is initiated by a light-activated G protein coupled pathway located on disc membranes in the photoreceptor cells. Signaling through this pathway involves the formation and activation of a variety of membrane-dependent protein complexes. We are studying the structures of these complexes as they exist on membrane surfaces through electron crystallography. We have formed two-dimensional crystals and helical arrays of the heterotrimeric form of the G protein and imaged them by cryo-electron microscopy. Image processing of the helical structures has revealed layer lines in the computed Fourier transform to beyond 18
, and indexing of these transforms is in progress.