EFFECT OF CORRECTION OF SLEEP DISORDERED BREATHING ON DAYTIME HYPERTENSION

本研究将探讨醒时血压与睡眠性呼吸暂停/低通气和与打鼾相关的高上呼吸道阻力之间的关系。我们将对轻中度高血压患者进行鼻腔持续气道正压通气（CPAP）治疗以消除睡眠呼吸障碍（SDB）和打鼾，并测定其对48小时动态血压测量和夜间儿茶酚胺释放的影响。我们假设，通过2周的鼻腔CPAP消除夜间呼吸可以降低伴有SDB和打鼾的轻/中度高血压患者的血压，但不会影响没有SDB和打鼾的患者的动脉压。我们预测，在CPAP治疗期间血压降低的受试者，夜间儿茶酚胺释放增加将与白天血压控制相关。本研究的主要目的是应用鼻腔CPAP，一种可以快速逆转SDB和打鼾的干预措施，以及在干预前、干预期间和干预后测量血压和尿儿茶酚胺释放量。

This study will investigate the relationship-of waking blood pressure to sleep-induced apnea/hypopnea and high upper airway resistance associated with snoring. We will experimentally eliminate sleep disordered breathing (SDB) and snoring with nasal continuous positive airway pressure (CPAP) treatment in mild and moderate hypertensives and determine the effect on 48 hour ambulatory blood pressure measurements and nocturnal catecholamine release. We hypothesize that the elimination of nocturnal respiratory with 2 weeks of nasal CPAP will result in a reduction in blood pressure in mild/moderate hypertensive subjects with SDB and snoring but will not affect arterial pressure in those subjects without SDB and snoring. We predict that increased nocturnal catecholamine release will be correlated with daytime blood pressure control in subjects who lower their blood pressure during CPAP therapy. The main objective of the study is the application of nasal CPAP, an intervention that can rapidly reverse SDB and snoring, and the measurement of blood pressures and urinary catecholamine release before, during and after the intervention.