XENOBIOTIC TRANSFER INTO MILK NITROFURANTOIN

这是一项临床研究，旨在测试三种靶向药物从血清到母乳的转运特性。产后哺乳的女性将被重新纳入研究。这些妇女将决定停止护理，在停止护理之前，将给予她们单剂量口服雷尼替丁或硝基呋喃妥因的菲莫替丁。将获得多个定时的血液和母乳样本，并对这些药物及其代谢物进行分析。数据将根据PI在兔子和其他动物研究的基础上设计的将药物转移到牛奶中的扩散模型进行评估。

This is a clinical study to test the transport characteristics from serum into human breast milk of three target drugs. Lactating postpartum females will be reruited into the study. These women will have decided to cease nursing and prior to cessation of nursing, they will be administered a single oral dose of Ranitidine of Phamotidine of Nitrofuratoin. Multiple timed samples of blood and breast milk will be obtained and analyzed for these drugs and their metabolytes. Data will be evaluated in terms of diffusional models for transfer of drugs into milk devised by the PI on the basis of studies in rabbits and other animals.