XENOBIOTIC TRANSFER INTO MILK NITROFURANTOIN

这是一项测试三种靶向药物从血清到人母乳转运特性的临床研究。哺乳期产后女性将被纳入研究。这些妇女将决定停止护理，在停止护理之前，她们将被给予单次口服雷尼替丁、帕莫替丁或呋喃托芬。将获得多次定时的血液和母乳样本，并分析这些药物及其代谢产物。数据将根据药物进入牛奶的扩散模型进行评估，该模型是PI根据对兔子和其他动物的研究设计的。

This is a clinical study to test the transport characteristics from serum into human breast milk of three target drugs. Lactating postpartum females will be reruited into the study. These women will have decided to cease nursing and prior to cessation of nursing, they will be administered a single oral dose of Ranitidine of Phamotidine of Nitrofuratoin. Multiple timed samples of blood and breast milk will be obtained and analyzed for these drugs and their metabolytes. Data will be evaluated in terms of diffusional models for transfer of drugs into milk devised by the PI on the basis of studies in rabbits and other animals.