SNI-2011 治疗干燥综合征患者-猫眼课题宝

SNI-2011 治疗干燥综合征患者

批准号：

6121144

负责人：

ALAN W FRIEDMAN

金额：

$1.51万

依托单位：

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

依托单位国家：

美国

项目类别：

财政年份：

1998

资助国家：

美国

项目状态：

已结题

起止时间：

1998-12-01 至 1999-11-30

来源：

https://reporter.nih.gov/project-details/6121144

关键词：

Sjogren's syndrome cholinergic agents clinical research human subject human therapy evaluation immunopathology chemotherapy

中文摘要

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英文摘要

Sjogren's syndrome is an immunological disorder characterized by dry eyes and dry mouth, which includes diminished or absent secretion of glandular tissue. SNI-2011, a quinuclidine derivative of acetylcholine, is a muscarinic agonist associated with improved glandular ability to increase salivation and lacrima-tion. This study will compare the efficacy of two doses of SNI-2011 (15 mg and 30 mg tid) with placebo on the patients' subjective global evaluation of dryness (mouth, eyes, and overall).

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