GENERAL CLINICAL RESEARCH CENTER

威斯康星州医学院的这一请求是为了 从1989年12月1日起至1989年11月31日止的额外五年期 1994年10月30日，支持目前在其 运营的第四年。 请求的支持是作为一个独立的中心，是为一个成年人 地理住院-门诊中心（天/访视/年）：住院患者： AS-1413、Bs-320（6张病床，入住率为79%）;门诊：AS-2368、Bs-529; 和儿科年龄分散床住院-门诊支持， (days住院病人：AS-144，Bs-709;门诊病人：AS-56， B-237 要求进行艾滋病相关研究的人数（天数/访问次数/年）： 住院病人：AS-176;门诊病人：AS-461。 在本申请中，31 同行评审和支持教师的主要研究人员和44高度 代表21所大学的合格教师共同研究员 威斯康星州部门已经贡献了46个多学科临床 研究协议。 威斯康星州大学有着悠久的传统 基础和临床跨学科研究，其医学院和 威斯康星州医院和诊所的大学提供了一个优秀的 创造富有想象力的临床研究环境。 研究 提交的方案代表了同行评审的基础和临床科学 研究者在当前和重要医学主题方面的举措 重要性 除了艾滋病外，重点研究的领域还包括 早产儿的肺部问题，以及患有囊性 纤维化;矿物质对年轻人的营养作用， 肌萎缩侧索硬化症患者;生物免疫学 反应调节剂;哮喘和骨髓移植中的免疫因素; 成人睡眠障碍;视杆细胞敏感性的眼科研究， 和青光眼;糖尿病、脂肪代谢、乳酸代谢紊乱 酸中毒、盐、情绪和抑郁以及母乳;生理影响 热疗、免疫和其他药物;药代动力学 癌症患者的细胞毒性药物参数;生理 护理程序的影响;以及 压力下的父母 教育机会的主要重点 医学院学生、家庭医生、博士后研究员和专职医疗人员 临床研究的受训人员受到重视。 的长期目标 这一GCRC将为新知识做出重大贡献， 生物医学科学通过有组织的跨学科研究 教师的基础科学和临床研究人员的活动，在 威斯康星州大学。

This request by the University of Wisconsin Medical School is for an additional five-year period beginning December 1, 1989 through November 30, 1994 in support of the General Clinical Research Center now in its 4th year of operation. Requested support is as a Discrete Center and is for an adolescent-adult geographic inpatient-outpatient center of (days/visits/year): Inpatient: As-1413, Bs-320 (6 beds at 79% occupancy); outpatient: As-2368, Bs-529; and pediatric age scatter bed inpatient-outpatient support of (days/visits/year): inpatient: As-144, Bs-709; Outpatient: As-56, Bs-237. Requested for AIDS-related research are (days/visits/year): Inpatient: As-176; Outpatient: As-461. In this application 31 peer-reviewed and supported faculty principal investigators and 44 highly qualified faculty co-investigators representing 21 University of Wisconsin Departments have contributed 46 multidisciplinary clinical research protocols. The University of Wisconsin has a long tradition of basic and clinical interdisciplinary research, and its medical school and University of Wisconsin Hospital and Clinics offer an excellent environment for imaginative clinical investigations. The research protocols submitted represent peer-reviewed basic and clinical science investigator initiatives in topics of current and significant medical importance. Areas of focused study in addition to AIDS, include pulmonary problems in premature infants, and children with cystic fibrosis; nutritional effects of minerals in young individuals, and patients with amyotrophic lateral sclerosis; immunology of biological response modifiers; immunologic factors in asthma and marrow transplant; disorders of sleep in adults; ophthalmologic studies of rod sensitivity, and glaucoma; metabolic disorders of diabetes, fat metabolism, lactic acidosis, salt, mood and depression, and human milk; physiologic effects of hyperthermia and immunologic and other agents; pharmacokinetic parameters of cytotoxic agents in patients with cancer; physiologic effects of nursing procedures; and psychosocial roles exhibited by parents under stress. Major emphases on educational opportunities for medical students, houseofficers, post-doctoral fellows, and allied health trainees in clinical research are stressed. The long term objective of this GCRC is to make significant contributions to new knowledge in biomedical science through organized interdisciplinary research activities of faculty basic science and clinical investigators at the University of Wisconsin.