HOST VIRUS INTERACTIONS DURING ACUTE INFECTION

艾滋病毒感染的早期事件，特别是病毒 和最初的宿主防御机制，很可能在 确定时间范围或随后的疾病进展。 了解这些组成部分，以及它们如何决定这一结果， 病毒和宿主之间的最初斗争将提供重要的 HIV发病机制和保护相关因素的线索 抵抗感染和疾病发展。 这项计划拨款专门用于对原发性艾滋病毒进行全面分析 来自艾滋病毒高度流行地区的一个独特研究小组的感染 在特立尼达的传播。 这一群体的主要特征包括 样本量大，无血液学偏倚，采样频繁， 临床终点和适当匹配对照的长期随访 科目 这项研究的总体目标是建立1）关系 早期乳腺癌和疾病进展之间的关系，2）提供更多的 更精细的解析HIV复制的动力学，通过频繁的 采样和3）将全面的主机响应与 病毒复制 该计划的最终目标是确定主机 最有效抑制HIV复制或 清除感染以及那些有利于艾滋病毒 传播并最终致病。 这些信息很可能 对制定预防和治疗战略至关重要， 利用宿主防御机制 该计划由四个高度互动的项目组成， 经验丰富的研究者与中心临床研究中心紧密联系， 核心 该计划的全面管理将受到一个计划的影响。 指导和管理核心。

Early events in HIV infection particularly the interplay between the virus and the initial host defense mechanisms, are likely to play major roles in determining the time frame or the subsequent progression to disease. understanding these components and how they dictate the outcome of this initial struggle between the virus and the host will provide important clues about the mechanism of HIV pathogenesis and correlates of protection against infection and disease progression. This program grant is dedicated to a comprehensive analysis of primary HIV infection ina unique study group from a highly endemic area of HIV transmission in Trinidad. The principal features of this cohort include large size, absence of bias for symptomatology, frequent sampling, long term follow-up for clinical endpoints and appropriately matched control subjects. The general aims of the study are to establish 1) relationships between early symptomatology and disease progression, 2) to provide a much finer resolution of the kinetic of HIV replication through frequent sampling and 3) to correlate a comprehensive range of host responses with viral replication. The ultimate goal of the program is to identify host responses that are most effective in suppressing HIV replication or in clearing the infection as well as those that are conducive to HIV dissemination and ultimately pathogenesis. Such information is likely to be important for design of preventive and therapeutic strategies that employ host defense mechanisms. The program is composed of four highly interactive projects led by experienced investigators that are tightly connected to a central Clinical Core. Overall management of the program will be effected by a Program Direction and Administration Core.