CORE--CLINICAL TRIAL PROTOCOL REVIEW AND MONITORING SYSTEM

方案评审系统包括1)癌症中心征集 机构协议的调查人员将接受审查，以获得 癌症中心的共享资源，2)会议审查 提交的机构议定书，以及3)议定书监测系统 确保及时执行和审查正在进行的议定书。 这一核心设施的主要目的是提供一个高效和 为下列成员生产转基因小鼠的经济手段 圣安东尼奥癌症研究所。转基因小鼠的建立 生产能力涉及大量投资，在这两个方面 用于装备和人员培训，因此，通常 对于只需要一小部分 转基因小鼠数量。此外，只有有限的转基因选择 圣安东尼奥癌症研究所已经可以生产老鼠 成员在过去，涉及商业生产的小鼠 或与少数几个人中的一个建立合作 UTHSCSA或CTRC内目前生产转基因的实验室 老鼠。因此，此核心的主要目标是提供SAN 安东尼奥癌症研究所成员通过一种方法可以将转基因小鼠 以反映实际成本的成本及时生产 生产小鼠的方法。其他相关服务将包括 无病原菌小鼠品系的重建及胚胎冷冻保存。

The protocol review system includes 1) solicitation of cancer center investigators for institutional protocols to be reviewed for access to the shared resources of the cancer center, 2) meetings to review submitted institutional protocols, and 3) a protocol monitoring system to assure timely conduct and review of ongoing protocols. The primary purpose of this core facility is to provide an efficient and economical means by which transgenic mice can be produced for members of the San Antonio Cancer Institute. The establishment of transgenic mouse production capabilities involves a substantial investment both in terms of equipment and in training of personnel and is, therefore, usually prohibitively expensive to individual laboratories requiring only a small number of transgenic mice. Further, only limited options for transgenic mouse production have been available to San Antonio Cancer Institute members in the past, involving either having mice produced commercially or establishing a collaboration with one of the small number of laboratories within the UTHSCSA or CTRC that currently produce transgenic mice. The primary objective of this core is therefore to provide San Antonio Cancer Institute members a means by which transgenic mice can be produced in a timely fashion and at a cost which reflects the actual cost of producing the mice. Additional, related services will include rederivation of pathogen-free mouse lines and embryo cryopreservation.