MEDICAL ONCOLOGY DEVELOPMENT RESEARCH
MEDICAL ONCOLOGY DEVELOPMENT RESEARCH
批准号:
6236373
负责人:
THOMAS Patrick MILLER
金额:
$18.14万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-12-15 至 1997-11-30
关键词:
SCID mouse biological response modifiers blood /lymphatic neoplasm breast neoplasms chemosensitizing agent clinical trials disease /disorder model human subject human therapy evaluation lymphoma multidrug resistance multiple myeloma neoplasm /cancer chemotherapy neoplasm /cancer pharmacology nonHodgkin's lymphoma pharmacokinetics statistics /biometry
中文摘要
0019 项目的核心重点是关联临床观察结果
根据实验室结果生成有关肿瘤的假设
进展或对治疗的反应,并检验这些新假设
诊所。 临床观察将来自集中于以下方面的研究
选择血液系统恶性肿瘤和乳腺癌。 肿瘤的形态
进展和治疗失败将指导实验室
制定克服毒品新方法的核心和项目
使用新药、化学增敏剂或药物变化产生耐药性
时间表或剂量。
项目的具体目标是:
1. 将临床观察结果作为实验室假设
实验室方向的调查和完善;
2. 开发针对特定血液病的新治疗方法
使用实验室开发的导线治疗恶性肿瘤和乳腺癌;
3. 研究癌症的生物学和基于科学的新疗法
通过将临床观察和治疗结果与
药代动力学、药物开发的体内和体外模型,以及
耐药性调查;
4. 检验实验室项目研究者提出的假设。
英文摘要
The central focus of Project 0019 is to correlate clinical observations
with laboratory results to generate hypotheses regarding tumor
progression or response to therapy, and to test these new hypotheses in
the clinic. Clinical observations will result from studies focused on
select hematologic malignancies and breast cancer. Patterns of tumor
progression and treatment failure will serve to guide the laboratory
cores and projects to produce new approaches to overcoming drug
resistance using novel drugs, chemosensitizers, or changes in drug
schedule or dosing.
The specific aims of project are:
1. To present clinical observations as hypotheses for laboratory
investigations and refinements of laboratory directions;
2. To develop new therapeutic approaches for select hematologic
malignancies and breast cancer using leads developed in the laboratory;
3. To study the biology and scientifically based new therapy of cancers
by interrelating clinical observations and treatment outcome with
pharmacokinetics, in vivo and in vitro models for drug development, and
the investigation of drug resistance;
4. To test hypotheses generated by investigators of laboratory projects.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
SOUTHWEST ONCOLOGY GROUP CA-13612
-
批准号:6341814
-
项目类别:
-
资助金额:$42.29万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP
-
批准号:3556197
-
项目类别:
-
资助金额:$25.27万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP
-
批准号:7224242
-
项目类别:
-
资助金额:$26.64万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP
-
批准号:3556198
-
项目类别:
-
资助金额:$22.12万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP
-
批准号:3556201
-
项目类别:
-
资助金额:$23.64万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP
-
批准号:7487227
-
项目类别:
-
资助金额:$2.0万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP CA-13612
-
批准号:6856680
-
项目类别:
-
资助金额:$11.92万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP
-
批准号:2086160
-
项目类别:
-
资助金额:$33.62万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP
-
批准号:2086161
-
项目类别:
-
资助金额:$25.0万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP
-
批准号:3556195
-
项目类别:
-
资助金额:$22.81万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP
-
批准号:3556193
-
项目类别:
-
资助金额:$22.03万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP
-
批准号:7038354
-
项目类别:
-
资助金额:$26.65万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP
-
批准号:7363699
-
项目类别:
-
资助金额:$26.65万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP CA-13612
-
批准号:2856179
-
项目类别:
-
资助金额:$40.72万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP
-
批准号:3556194
-
项目类别:
-
资助金额:$33.0万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP
-
批准号:2086162
-
项目类别:
-
资助金额:$34.98万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP CA-13612
-
批准号:2456976
-
项目类别:
-
资助金额:$39.96万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP CA-13612
-
批准号:6489007
-
项目类别:
-
资助金额:$44.03万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP
-
批准号:7561020
-
项目类别:
-
资助金额:$27.12万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
SOUTHWEST ONCOLOGY GROUP
-
批准号:2007158
-
项目类别:
-
资助金额:$20.36万
-
财政年份:1978
-
负责人:THOMAS Patrick MILLER
-
依托单位:
海外基金