MEDICAL ONCOLOGY DEVELOPMENT RESEARCH

项目0019的中心重点是将临床观察结果 与实验室结果，以产生关于肿瘤的假设 进展或对治疗的反应，并测试这些新的假设， 诊所 临床观察结果将来自于以下研究： 选择恶性血液病和乳腺癌。 肿瘤类型 进展和治疗失败将用于指导实验室 核心和项目，以产生克服毒品的新方法 使用新药、化疗增敏剂或药物变化引起的耐药性 时间表或剂量。 项目的具体目标是： 1. 将临床观察结果作为实验室检查的假设 研究和改进实验室指导; 2. 为选择性血液病开发新的治疗方法 使用实验室开发的电极导线治疗恶性肿瘤和乳腺癌; 3. 研究癌症的生物学和基于科学的新疗法 通过将临床观察和治疗结果与 药代动力学、药物开发的体内和体外模型，以及 耐药性调查; 4. 检验实验室项目研究人员提出的假设。

The central focus of Project 0019 is to correlate clinical observations with laboratory results to generate hypotheses regarding tumor progression or response to therapy, and to test these new hypotheses in the clinic. Clinical observations will result from studies focused on select hematologic malignancies and breast cancer. Patterns of tumor progression and treatment failure will serve to guide the laboratory cores and projects to produce new approaches to overcoming drug resistance using novel drugs, chemosensitizers, or changes in drug schedule or dosing. The specific aims of project are: 1. To present clinical observations as hypotheses for laboratory investigations and refinements of laboratory directions; 2. To develop new therapeutic approaches for select hematologic malignancies and breast cancer using leads developed in the laboratory; 3. To study the biology and scientifically based new therapy of cancers by interrelating clinical observations and treatment outcome with pharmacokinetics, in vivo and in vitro models for drug development, and the investigation of drug resistance; 4. To test hypotheses generated by investigators of laboratory projects.