MEDICAL ONCOLOGY DEVELOPMENT RESEARCH

0019 项目的核心重点是关联临床观察结果 根据实验室结果生成有关肿瘤的假设 进展或对治疗的反应，并检验这些新假设 诊所。 临床观察将来自集中于以下方面的研究 选择血液系统恶性肿瘤和乳腺癌。 肿瘤的形态 进展和治疗失败将指导实验室 制定克服毒品新方法的核心和项目 使用新药、化学增敏剂或药物变化产生耐药性 时间表或剂量。 项目的具体目标是： 1. 将临床观察结果作为实验室假设 实验室方向的调查和完善； 2. 开发针对特定血液病的新治疗方法 使用实验室开发的导线治疗恶性肿瘤和乳腺癌； 3. 研究癌症的生物学和基于科学的新疗法 通过将临床观察和治疗结果与 药代动力学、药物开发的体内和体外模型，以及 耐药性调查； 4. 检验实验室项目研究者提出的假设。

The central focus of Project 0019 is to correlate clinical observations with laboratory results to generate hypotheses regarding tumor progression or response to therapy, and to test these new hypotheses in the clinic. Clinical observations will result from studies focused on select hematologic malignancies and breast cancer. Patterns of tumor progression and treatment failure will serve to guide the laboratory cores and projects to produce new approaches to overcoming drug resistance using novel drugs, chemosensitizers, or changes in drug schedule or dosing. The specific aims of project are: 1. To present clinical observations as hypotheses for laboratory investigations and refinements of laboratory directions; 2. To develop new therapeutic approaches for select hematologic malignancies and breast cancer using leads developed in the laboratory; 3. To study the biology and scientifically based new therapy of cancers by interrelating clinical observations and treatment outcome with pharmacokinetics, in vivo and in vitro models for drug development, and the investigation of drug resistance; 4. To test hypotheses generated by investigators of laboratory projects.