CORE--SAMPLE COLLECTION, FRACTIONATION, DISTRIBUTION AND STORAGE

该CML计划项目赠款代表了一个综合计划，该计划包括 医学博士内部的7个部门、2个部门和1个独立项目。 安德森癌症中心。临床与实验室的互动 项目旨在促进建立新的治疗方法 慢性粒细胞白血病的方向和实验室分析的发展将是 有助于确定治疗敏感性的决定因素 测量响应。这些生物学研究将为 治疗的新方向。为了实现这一计划目标，一个 其中程序化的收集、分离、分配和 样品的储存，与临床和实验室密切相关 节目是可以进行的。 这个治疗研究项目涉及到对分子的分析 以及在反应或反应的进化过程中发生的生物变化 对化疗药物的抗药性，联合生物和 化疗和骨髓移植。血清外周血 每隔一段预定的时间间隔收集几个单元 顺序治疗干预措施，如图1和图2所示 表I.必须将这些样本分发给相应的项目 所有项目1-6的合作者。外周血移植剂量 通过体外培养操纵的单个核细胞或骨髓细胞必须 被收集、处理、存储并重新注入到接受治疗的患者 自体或异基因骨髓移植。这个核心是 旨在提供对这些信息的收集、处理和分析 样本。

This CML program project grant represents an integrated program consisting of 7 Departments, 2 Divisions and 1 independent program within M.D. Anderson Cancer Center. The interaction of the clinical and laboratory programs is designed to foster the establishment of new therapeutic directions for CML and the development of laboratory assays which will be of help in identifying determinants of therapy sensitivity and in measuring response. These biological studies will provide the basis for new directions in therapy. In order to accomplish this program goal, a core in which the programmed collection, fractionation, distribution and storage of samples, in close affiliation with the clinical and laboratory programs can take place. This therapeutic research program involves the analysis of the molecular and biological changes which occur during the evolution of response or resistance to chemotherapeutic agents, combined biological and chemotherapy and bone marrow transplantation. Serum peripheral blood cells are to be collected at predetermined intervals throughout several sequential therapeutic interventions, outlined in Figures 1 and 2 and Table I. These samples must be distributed to the appropriate project collaborator in all Projects 1-6. Engrafting doses of peripheral blood mononuclear cells or bone marrow cells manipulated by in vitro growth must be collected, processed, stored and re-infused into patients undergoing autologous or allogeneic bone marrow transplantation. This core is designed to provide for the collection, processing and analysis of these samples.