MOLECULAR AND GENETIC ANALYSIS OF MUSCLE SPECIFIC GENES
肌肉特异性基因的分子和遗传分析
基本信息
- 批准号:6240493
- 负责人:
- 金额:$ 3.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-02-01 至 1998-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Muscle cells possess a number of unique functional characteristics which
set them apart from other cell types in higher organisms - most notably
those related to excitability, the coupling of an electrical signal into
muscle contraction and the contractile process itself. The long term
goals of the proposed research are to understand these cellular processes
at the level of the molecular mechanisms which underlie muscle cell
function. The immediate aims of the proposed work will be to begin to
isolate and to characterize genes which we have putatively identified to
be expressed specifically in muscle cells of adult organisms and not in
other cell types. It is postulated that these genes may encode proteins
that are involved in the unique processes of the muscle cell. This work
will entail the use of a recently devised molecular scheme involving the
fruitfly Drosophila, which allows one to identify easily the spatial and
temporal expression pattern of genes which have been mutagenized or are
close to the site of a mutation generated by the insertion of genetically
engineered transposable p-elements into the genome. Once identified, the
muscle-specific genes will be subjected to further molecular analyses
which include cytogenetic mapping of the physical location of the genes
on polytene chromosomes and the isolation, cloning and characterization
of genes of interest. Ultimately this approach may aid in understanding
the structure, function and role of proteins involved in muscle cell
function.
Funds are requested to support one undergraduate and one graduate
student. The undergraduate student will learn basic laboratory skills
and specific skills related to his/her project under the direction of the
P.I. and will be supervised on a daily basis by a postdoctoral fellow or
advanced graduate students. By the second year, the undergraduate will
be encouraged to work independently on a portion of the proposed studies.
The graduate student will be supervised by the P.I. and will learn to
become an independent scientist. All students will attend weekly lab
meetings and seminars and will be expected to communicate the results of
their studies at regional and appropriate national meetings.
肌肉细胞具有许多独特的功能特征
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Greg L Harris其他文献
Greg L Harris的其他文献
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{{ truncateString('Greg L Harris', 18)}}的其他基金
Genetic analysis of sphingolipid metabolism and obesity
鞘脂代谢与肥胖的遗传分析
- 批准号:
6876225 - 财政年份:2004
- 资助金额:
$ 3.66万 - 项目类别:
Genetic analysis of sphingolipid metabolism and obesity
鞘脂代谢与肥胖的遗传分析
- 批准号:
6952382 - 财政年份:2004
- 资助金额:
$ 3.66万 - 项目类别:
MOLECULAR AND GENETIC ANALYSIS OF MUSCLE SPECIFIC GENES
肌肉特异性基因的分子和遗传分析
- 批准号:
6576903 - 财政年份:2002
- 资助金额:
$ 3.66万 - 项目类别:
MOLECULAR AND GENETIC ANALYSIS OF MUSCLE SPECIFIC GENES
肌肉特异性基因的分子和遗传分析
- 批准号:
6435880 - 财政年份:2001
- 资助金额:
$ 3.66万 - 项目类别:
MOLECULAR AND GENETIC ANALYSIS OF MUSCLE SPECIFIC GENES
肌肉特异性基因的分子和遗传分析
- 批准号:
6301824 - 财政年份:2000
- 资助金额:
$ 3.66万 - 项目类别:
MOLECULAR AND GENETIC ANALYSIS OF MUSCLE SPECIFIC GENES
肌肉特异性基因的分子和遗传分析
- 批准号:
6107961 - 财政年份:1999
- 资助金额:
$ 3.66万 - 项目类别:
MOLECULAR AND GENETIC ANALYSIS OF MUSCLE SPECIFIC GENES
肌肉特异性基因的分子和遗传分析
- 批准号:
6107586 - 财政年份:1998
- 资助金额:
$ 3.66万 - 项目类别:
DEVELOPMENT OF GABA CHANNELS IN CULTURED NEURONS
培养神经元中 GABA 通道的发育
- 批准号:
3053773 - 财政年份:1986
- 资助金额:
$ 3.66万 - 项目类别:
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