ARDS--CLINICAL EPIDEMIOLOGY AND ROLE OF THE INFLAMMATORY RESPONSE
ARDS--临床流行病学和炎症反应的作用
基本信息
- 批准号:6241804
- 负责人:
- 金额:$ 20.71万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1996
- 资助国家:美国
- 起止时间:1996-12-01 至 1997-11-30
- 项目状态:已结题
- 来源:
- 关键词:adult respiratory distress syndrome blood toxicology cytokine disease /disorder proneness /risk human subject interleukin 8 leukocyte adhesion molecules lung injury lung lavage neutrophil pathology prognosis protease inhibitor respiratory disorder diagnosis respiratory disorder epidemiology respiratory infections von Willebrand factor
项目摘要
This project will investigate the epidemiology of ARDS and the evolution
of the inflammatory process in patients with acute lung injury. The
epidemiological aspects will focus on refining our clinical criteria that
predict patients at high risk for the onset of ARDS, and identifying
these patients as early as possible before the onset of lung injury. Our
major hypothesis is that uncontrolled and sustained alveolar inflammation
increases the severity of ARDS and prolongs its course, and that
sustained inflammation is more likely to occur when ARDS follows sepsis
syndrome than multiple trauma. We also will investigate the hypothesis
that the pattern of the inflammatory response in blood and lungs is an
important determinant of whether lung inflammation persists of resolves.
Important components of the inflammatory response that we intend to study
include; 1) a coordinated sequence of cytokines in blood and lung lavage
fluid; 2) the expression of adhesion molecules on blood leukocytes; 3)
circulating markers of diffuse endothelial injury (VWF and ELAM1); 4)
products of the arachidonic acid cascade; 5) the induction of endogenous
proteins that modify the host response to bacterial products such as
endotoxin; and 6) inflammatory cell populations and proteins in the lung.
We will correlate patterns of inflammation with clinical risks,critical
clinical events, and outcome measures. We expect that our results will
provide: a) a better understanding of the evolution of inflammation in
clinical conditions leading to lung injury; b) a better understanding of
the mechanisms of the initial injury and its propagation; and c)
information that will help predict the course and outcome in individual
patients. We also expect that these data will be useful in guiding the
choice and timing of specific therapeutic interventions.
本项目将调查ARDS的流行病学及其演变
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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LEONARD D HUDSON其他文献
LEONARD D HUDSON的其他文献
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{{ truncateString('LEONARD D HUDSON', 18)}}的其他基金
EPIDEMIOLOGY AND INFLAMMATORY RESPONSES IN ACUTE LUNG INJURY
急性肺损伤的流行病学和炎症反应
- 批准号:
6564874 - 财政年份:2001
- 资助金额:
$ 20.71万 - 项目类别:
EPIDEMIOLOGY AND INFLAMMATORY RESPONSES IN ACUTE LUNG INJURY
急性肺损伤的流行病学和炎症反应
- 批准号:
6302180 - 财政年份:1999
- 资助金额:
$ 20.71万 - 项目类别:
EPIDEMIOLOGY AND INFLAMMATORY RESPONSES IN ACUTE LUNG INJURY
急性肺损伤的流行病学和炎症反应
- 批准号:
6109704 - 财政年份:1998
- 资助金额:
$ 20.71万 - 项目类别:
ARDS--CLINICAL EPIDEMIOLOGY AND ROLE OF THE INFLAMMATORY RESPONSE
ARDS--临床流行病学和炎症反应的作用
- 批准号:
6272687 - 财政年份:1997
- 资助金额:
$ 20.71万 - 项目类别:














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