CORE--GERIATRIC PSYCHOPHARMACOLOGY

老年精神药理学实验室的拟议活动 来自CRC在这一领域正在进行的研究和 宾夕法尼亚大学精神药理学项目的长期利益。的 实验室旨在提供一个结构， 对精神疾病药物治疗的研究 用于治疗疾病的药物对生命和精神的影响; 它提供基础设施支持，以开发新的研究，并支持 初级调查员的发展。本文中描述的研究 申请包括两项研究，“去甲替林治疗 疗养院老年人的抑郁症”和“谵妄的再思考： 老年人急性认知变化监测”， 通过CRC倡议，现在独立资助，以及两个 新项目，“舍曲林的安全性和有效性的初步研究， 心肌梗塞后抑郁症“和“心肌梗塞后抑郁症的刺激反应” 老年抑郁症：治疗和探索。舍曲林研究是 提出的原因是，使用该药物观察到的不良事件特征 这样，现在可能第一次有可能进行更大的 心梗后抑郁症治疗的对照研究 患者评估治疗的功能结局以及 减少症状;然而，在进行此类研究之前， 有必要确认舍曲林的安全性，特别是在MI后 患者兴奋剂研究是一项安慰剂对照研究， 哌甲酯治疗抑郁症的住院康复 在这种情况下，反应速度对于克服 抑郁症的影响作为康复过程的障碍;它是 还设计开发刺激性挑战，作为异质性测试 在老年患者情感调节的胺能系统中 患有慢性病

The proposed activities of the Laboratory of Geriatric Psychopharmacology are derived from both the CRC's ongoing studies in this area and from the longstanding interests of Penn's program m psychopharmacology. The Laboratory is designed to provide a structure that will facilitate research on both the drug treatment of the psychiatric disorders of late life and the psychiatric effects of drugs used to treat medical disorders; it provides infrastructure support to develop new research and to support the development of junior investigators. The research described in this application consists of two studies, "Nortriptyline Treatment of Depression in the Nursing Home Aged", and "Delirium Reconsidered: Monitoring for Acute Cognitive Change in the Elderly" that were developed through CRC initiatives and are now independently funded as well as two new projects, "A Pilot Study of the Safety and Efficacy of Sertraline in Depression after Myocardial Infarction ", and "Stimulant Responses in Geriatric Depression: Treatment and Probe". The Sertraline study is proposed because the profile of adverse events observed with this agent is such that it may now, for the first time, be possible to conduct larger scale controlled studies of the treatment of depression in post-mi patients to assess the functional outcome of treatment as well as the reduction in symptoms; however, before such research can be conducted it is necessary to confirm the safety of sertraline specifically in post-mi patients. The Stimulant study is a placebo-controlled study of methylphenidate treatment for depression in the inpatient rehabilitation setting, where rapidity of response can be important to overcome the effects of depression as a barrier to the process of rehabilitation; it is also designed to develop stimulant challenges as tests for heterogeneity in aminergic systems underlying the regulation of affect in older patients with chronic disease.