CHRONIC COCAINE EXPOSURE DURING GESTATION:PRENATAL

这个项目的目标是在一个非人类的 灵长类动物模型产前可卡因暴露的影响， 更好地了解与可卡因使用有关的风险， 怀孕 临床报告表明，越来越多的 的孕妇在入院时可卡因检测呈阳性， 医院在分娩期间，这些妇女和她们的新生儿在 增加了一些异常的风险。 然而，直接 可卡因对妊娠结局的影响难以确定， 人类，因为有很多因素。 这个项目是 在恒河猴身上研究可卡因给药的后果 以表征对妊娠的影响 女性，发育中的胎儿和由此产生的后代在一个 受控的实验室环境， 可卡因是可以确定的。 在过去的一年里，可卡因暴露 幼鱼及其配对喂养的对照组进行了几项测试 以及对药物干扰的敏感性 的行为表现。 此外，相当多的 已经致力于开发静脉内药物 自我管理方案。 血管通路端口提供了 静脉注射可卡因的有效方法，以及一组 受试者已经被训练来执行一项行为任务， 运送可卡因 获取率、对各种 剂量的可卡因，以及对药物拮抗作用的敏感性， 可卡因的强化作用将决定产前接触 对可卡因有长期的影响， 可卡因滥用的风险

The objectives of this project are to investigate in a nonhuman primate model the effects of prenatal cocaine exposure in order to understand better the risks associated with cocaine use during pregnancy. Clinical reports have indicated that an increasing number of pregnant women test positive for cocaine when admitted to the hospital during labor, and that these women and their newborns are at increased risk for a number of abnormalities. However, the direct effects of cocaine on pregnancy outcome are difficult to ascertain in humans because of a number of confounding factors. This project is studying in rhesus monkeys the consequences of cocaine administration during gestation in order to characterize effects on the pregnant female, the developing fetus and the resulting offspring in a controlled laboratory environment where the direct contribution of cocaine can be determined. During the past year, cocaine-exposed juveniles and their pair-fed controls were tested on s everal measures of cognition and memory, and sensitivity to pharmacological disruption of behavioral performances was determined. In addition, considerable effort has been directed toward the development of intravenous drug self-administration protocols. Vascular access ports have provided an effective means to administer cocaine intravenously, and a group of subjects has been trained to perform a behavioral task that results in cocaine delivery. The rate of acquisition, sensitivity to various doses of cocaine, and susceptibility to pharmacological antagonism of cocaine's reinforcing effects will determine whether prenatal exposure to cocaine has long-term consequences that can affect the likelihood of cocaine abuse in adulthood.