ANALYSIS, BIOLOGY, CORRECTION OF CRANIOFACIAL DISORDERS

颅面疾病的分析、生物学、矫正

• 批准号: 2397508
• 负责人: JOEL ROSENBLOOM
• 金额: $ 15.9万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 1998-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2397508
• 关键词: biomedical facility; congenital oral /facial /cranial defect; craniofacial; dental health education; dental research; education evaluation /planning; information dissemination; oral health

We propose to develop a Comprehensive Oral Health Research Center of Discovery (COHRCD) with a focus on the analysis, biology and correction of craniofacial abnormalities. This Center will involve the efforts of several entities within the University of Pennsylvania (U of P) Center for the Health Care Sciences. These entities include the School of Dental Medicine, the Children's Hospital of Philadelphia (a teaching hospital of the U of P School of Medicine), the Leonard Davis Institute and other collaborative organizations that will benefit by sharing expertise and research results. The fundamental goal of the proposed program is to facilitate greater understanding, information sharing and exchange of research findings in the areas of craniofacial development and bone biology as related to heritable diseases. Our working objective is to capitalize on the existing, extensive clinical and basic science expertise related to the COHRCD research theme at the U of P and of our regional colleagues. In the COHRCD, investigators from different disciplines will be provided with the framework within which to share resources and exchange information pertaining to multiple aspects of normal and abnormal craniofacial morphogenesis. In order to develop this center, we propose to initiate a planning process. This planning phase will allow us to develop the infrastructure and secure interinstitutional commitments for the future regional Center of Excellence. Thus, we will: 1. Integrate the biomedical, behavioral, social science and health services research bases of the collaborating institutions. 2. Develop a demonstration research component that will include outreach and community liaison functions. 3. Develop a research program that involves education of health professionals and scientists as well as the communities served by the collaborating institutions. 4. Develop a technology transfer component that will facilitate and hasten the implementation of advances made in the Center. 5. Create strong administrative and research support cores that will provide the structure for coordinating the activities of the Center and ensuring efficient use of resources. Establishing a center with a focus in understanding the biology of craniofacial anomalies will lead to advances in this programmatic area. These advances will be used to develop new and more powerful diagnostic and corrective measures which will be applicable to both pediatric and adult populations.

我们建议成立一个综合口腔健康研究中心， 发现（COHRCD），重点是分析，生物学和校正 颅面畸形的症状该中心将涉及以下方面的努力： 宾夕法尼亚大学（U of P）中心内的几个实体 for the Health健康Care护理Sciences科学.这些机构包括： 牙科医学，费城儿童医院（教学 宾夕法尼亚大学医学院医院）、伦纳德戴维斯研究所 以及其他合作组织， 专业知识和研究成果。建议的基本目标 该计划旨在促进更好的理解，信息共享和 交流颅面发育领域的研究成果 以及与遗传性疾病相关的骨骼生物学。我们的工作目标 是利用现有的广泛的临床和基础科学 在P和我们的大学与COHRCD研究主题相关的专业知识 区域同事。在该中心，来自不同国家的调查人员 将为学科提供一个框架， 资源和交流信息涉及的多个方面， 正常和异常颅面形态发生。为了开发这个 中心，我们建议启动一个规划过程。这个规划阶段 将使我们能够发展基础设施， 机构间承诺， 卓越因此，我们将： 1.整合生物医学、行为科学、社会科学和健康 服务合作机构的研究基地。 2.制定一个示范研究部分，其中将包括外联活动 社区联络功能。 3.制定一项涉及健康教育的研究计划 专业人员和科学家以及社区服务的 合作机构。 4.制定一个技术转让组成部分， 加快推进中心建设。 5.建立强有力的行政和研究支持核心， 提供协调中心活动的结构， 确保有效利用资源。 建立一个中心，重点是了解生物学 颅面异常将导致这一方案领域的进展。 这些进展将用于开发新的和更强大的诊断 和纠正措施，将适用于儿科和 成人人口。