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BROMODEOXYURIDINE AND RADIATION THERAPY FOR CARCINOMA OF THE CERVIX, VAGINA

BROMODEOXYURIDINE AND RADIATION THERAPY FOR CARCINOMA OF THE CERVIX, VAGINA
溴脱氧尿嘧啶和放射治疗宫颈癌、阴道癌
批准号：
6244537
负责人：
Avraham Eisbruch
金额：
$2.22万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-02-20 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6244537
关键词：
bromodeoxyuridine carcinoma cervix neoplasms clinical research clinical trials combination cancer therapy drug administration rate /duration drug screening /evaluation endometrium female human subject human therapy evaluation neoplasm /cancer chemotherapy neoplasm /cancer radiation therapy neoplasm /cancer relapse /recurrence uterus neoplasms vagina neoplasms women's health

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英文摘要
Preclinical data has shown that administering RT and thymidine analog radiosensitizer in an alternating weekly schedule may allow clinically significant radiosensitization without markedly increased toxicity. This is a dose seeking trial of the use of the thymidine analog bromodeoxyuridine (BrdUrd) and RT for the treatment of patients with locally advanced or recurrent carcinoma of the cervix, vagina and endometrium.
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